摘要
目的分别评估中性粒细胞/HDL-C比值(NHR)、单核细胞/HDL-C比值(MHR)对不同海拔地区颅内外动脉粥样硬化患者的临床预测价值。方法收集不同海拔地区经颅数字减影血管造影术(DSA)检查诊断为颅内外动脉粥样硬化性狭窄患者120例,其中高、中、低海拔地区各40例分别为观察3组、观察2组和观察1组,另外选取高、中、低海拔地区年龄、性别基本匹配的DSA检查正常者各40例为对照3组、对照2组和对照1组。对比各组临床基线资料及化验指标,计算NHR和MHR。采用ROC曲线分析NHR和MHR对颅内外动脉粥样硬化狭窄的预测作用。结果对照1、2、3组尿酸、HDL-C及NHR水平比较,差异有统计学意义(P<0.01)。观察1、2、3组白细胞计数(WBC)、中性粒细胞、尿酸、TC、LDL-C及NHR水平比较,差异有统计学意义(P<0.05,P<0.01)。观察1组WBC、中性粒细胞、淋巴细胞、单核细胞明显高于对照1组,HDL-C明显低于对照1组(P<0.05,P<0.01);观察2组WBC、中性粒细胞、单核细胞明显高于对照2组,HDL-C明显低于对照2组(P<0.05,P<0.01);观察3组WBC、中性粒细胞、单核细胞明显高于对照3组,HDL-C明显低于对照3组(P<0.05,P<0.01)。ROC曲线分析显示,NHR对低、中、高海拔地区颅内外动脉粥样硬化狭窄预测的ROC曲线下面积(AUC)分别为0.736(95%CI:0.625~0.828)、0.755(95%CI:0.646~0.844)、0.779(95%CI:0.672~0.864),MHR的AUC分别为0.765(95%CI:0.657~0.853)、0.772(95%CI:0.665~0.859)、0.788(95%CI:0.683~0.872)。结论NHR、MHR对颅内外动脉粥样硬化性狭窄有较强的预测价值,并随着海拔增高,其预测价值越大。
Objective To assess the clinical value of neutrophils to HDL-C ratio(NHR)and monocytes to HDL-C ratio(MHR)for predicting atherosclerotic stenosis in intracranial and extracranial atherosclerosis patients at different altitudes.Methods One hundred and twenty intracranial and extracranial atherosclerosis patients at high,medium and low altitudes diagnosed by transcranial DSA were divided into observation group 3,observation group 2 and observation group 1(40 in each group)with 40 age-and sex-matched healthy persons from high,medium and low altitudes served as control group 3,control group 2 and control group 1.Their baseline clinical data and laboratory testing parameters were compared.The NHR and MHR in different groups were recorded.The role of NHR and MHR in predicting intracranial and extracranial atherosclerotic stenosis was analyzed by ROC curve analysis.Results Significant difference was detected in serum UA and HDL-C levels and NHR in control groups 1-3(P<0.01)and in WBC,neurophils,serum UA,TC and LDL-C levels and NHR in observation groups 1-3(P<0.05,P<0.01).The number of WBC,neutrophils and monocytes was significantly greater while the serum level of HDL-C was significantly lower in observation group 2 than in control group 2(P<0.05,P<0.01)and in observation group 3 than in control group 3(P<0.05,P<0.01).ROC curve analysis showed that the AUC of NHR for predicting intracranial and extracranial atherosclerotic stenosis at low,medium and high altitudes was 0.736(95%CI:0.625-0.828),0.755(95%CI:0.646-0.844),0.779(95%CI:0.672-0.864)respectively and the AUC of MHR for predicting intracranial and extracranial atherosclerotic stenosis at low,medium and high altitudes was 0.765(95%CI:0.657-0.853),0.772(95%CI:0.665-0.859),0.788(95%CI:0.683-0.872)and 0.788(95%CI:0.683-0.0.872)respectively.Conclusion NHR and MHR can predict the intracranial and extracranial atherosclerotic stenosis and increase with the increasing altitude.
作者
刘著
吴世政
樊青俐
雷延成
Liu Zhu;Wu Shizheng;Fan Qingli;Lei Yancheng(Department of Neurology,Qinghai Provincial People’s Hospital,Xining,810007,Qinghai Province,China)
出处
《中华老年心脑血管病杂志》
北大核心
2021年第10期1073-1076,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
青海省临床医学研究中心项目(2017-SF-L1)
2020年青海省卫生健康科研课题项目(2020-wjzdx-29)。
作者简介
通信作者:吴世政,Email:wushizheng2005@hotmail.com;通信作者:樊青俐,Email:fql771017@126.com。
