摘要
目的利用临床和影像特征建立模型,评估模型诊断透明细胞型肝癌的价值。资料与方法回顾性分析经病理证实、并行术前CT平扫联合增强扫描的42例透明细胞型肝癌和109例普通型肝细胞癌患者的资料,以7∶3将两组患者随机分为训练集和验证集,记录所有患者的临床及影像特征,对训练集的病例资料进行统计学分析,并建立鉴别透明细胞型肝癌和普通型肝细胞癌的Logistic模型,利用验证集病例对模型进行验证。结果透明细胞型肝癌和普通型肝细胞癌的丙肝发生率分别为24.24%、5.19%,肿瘤内脂肪密度出现率分别为21.21%、2.59%,肿瘤CT平扫密度均匀性出现率分别为18.18%、48.05%,门静脉内瘤栓出现率分别为3.03%、16.88%,瘤内动脉征出现率分别为27.27%、49.35%,以上5项特征差异均有统计学意义(P<0.05)。利用以上5项特征建立的Logistic模型在训练集和验证集鉴别透明细胞型肝癌和普通型肝细胞癌的准确率分别为78.2%、75.6%。普通型肝细胞癌在训练集和验证集的真阳性率分别为83.1%、87.5%;透明细胞型肝癌在训练集和验证集的真阳性率分别为66.7%和33.3%。结论临床和影像特征建立的Logistic模型诊断透明细胞型肝癌有一定的价值。
Purpose To establish a comprehensive model via clinical and imaging features,and to evaluate the diagnostic value of the comprehensive model in clear cell hepatocellular carcinoma.Materials and Methods Forty-two patients with clear cell hepatocellular carcinoma and 109 patients with common hepatocellular carcinoma were retrospectively selected,and all of the patients were pathologically confirmed.The data of the preoperative CT plain scan images and enhanced scan images were also analyzed.All patients were randomly divided into training set and validation set at a ratio of 7∶3.The clinical and imaging features of all patients were recorded,the data of the training set cases were statistically analyzed,and a Logistic model was established to distinguish clear cell hepatocellular carcinoma from common hepatocellular carcinoma.The comprehensive model was verified with the validation set.Results The incidence of hepatitis C in patients with clear cell hepatocellular carcinoma and in patients with common hepatocellular carcinoma were 24.24%and 5.19%;the incidence of intratumoral fat density were 21.21%and 2.59%;the incidence of uniformity of tumor density uniformity of CT scan were 18.18%and 48.05%;the incidence of tumor thrombus in portal vein were 3.03%and 16.88%;the incidence of intratumoral artery sign were 27.27%and 49.35%,respectively.There were statistically significant differences in the above five features between two groups(P<0.05).Based on the Logistic model established by the above five features,the accuracy of the training set and validation set were 78.2%and 75.6%,respectively,distinguishing the clear cell hepatocellular carcinoma from the common hepatocellular carcinoma.The true positive rate of common hepatocellular carcinoma in the training set and validation set were 83.1%and 87.5%;the true positive rate of clear cell hepatocellular carcinoma in the training set and validation set were 66.7%and 33.3%,respectively.Conclusion The Logistic model established by clinical and imaging features has certain diagnostic value in clear cell hepatocellular carcinoma.
作者
刘斌
孙君
陈枫
李宏军
LIU Bin;SUN Jun;CHEN Feng;LI Hongjun(Department of Radiology,Beijing YouAn Hospital,Capital Medical University,Beijing 100069,China)
出处
《中国医学影像学杂志》
CSCD
北大核心
2021年第9期897-901,共5页
Chinese Journal of Medical Imaging
基金
国家自然科学基金重点项目(61936013)。
作者简介
通信作者:李宏军,lihongjun00113@126.com。
