摘要
Subjective tinnitus is the most common type of tinnitus, which is the manifestation of pathologicalactivities in the brain. It happens in a substantial portion of the general population and brings significantburden to the society. Severe subjective tinnitus can lead to depression and insomnia and severely affectspatients’ quality of life. However, due to poor understanding of its etiology and pathogenesis, treatmentof subjective tinnitus remains challenging. In recent decades, a growing number of studies have shownthat subjective tinnitus is related to lesion-induced neural plasticity of auditory and non-auditory centralsystems. This article reviews cellular mechanisms of neural plasticity in subjective tinnitus to providefurther understanding of its pathogenesis.
基金
This work was supported by the National Natural Science Foundation of China under Grant[81820108009]
Beijing Municipal Science and Technology Commission under Grant[Z161100000116038]
Beijing Municipal Health Commission under Grant[2016-1-5014]
Beijing Nova Program[Z201100006820133]
the National Key Research and Development Project[2019YFC0121302]
the National Key Research and Development Project[2019YFC0840707].
作者简介
Qi Zhang,E-mail addresses:zhangqi_ent@163.com;Lidong Zhao,E-mail addresses:plagh@126.com;Corresponding author:Weidong Shen.E-mail addresses:wdshen@hotmail.com;Corresponding author:Shiming Yang.E-mail addresses:yangshiming@301hospital.com.cn。
