摘要
In the last decades,a variety of nuclear magnetic resonance(NMR)techniques have been applied with success in the field of advanced functional materials,including the important area of drug delivery.In such field,solid-state NMR(SSNMR)is an irreplaceable tool in the arsenal of characterization techniques,offering unique and comprehensive perspectives for the description of chemical structure,spatial connectivity and interfacial phenomena of solid dosage forms.This review focuses on the widespread applications of SSNMR in drug delivery field,an overview of selected case studies is provided,together with possible developments.
基金
This work was supported by National Natural Science Foundation of China(grant no.21922410)
National Natural Science Foundation of China(grant no.22072133)
Zhejiang Provincial Natural Science Foundation(grant no.LR19B050001)
National Key Research and Development Program of China(grant no.2016YFA0203600).
作者简介
Alessandro Marchetti,Dr. Marchetti studied chemistry at the University of Pisa, receiving his B.Sc. and his M.Sc. in 2005 and 2007,respectively. In 2012, he obtained his Ph.D. in chemistry from ENS Lyon and SNS Pisa under the co-supervision of Prof. C. A. Veracini,Prof. L. Emsley and Dr. G. Pintacuda. He worked as a laboratory technician in the field of oceanography at JRC Ispra, and as a PostDoc at ZJU under Prof. X. Kong. He is currently an expert of scientific outreach and metadata for cultural heritage and bibliometry,Equal contribution;Jinglin Yin,Miss Yin received the B.S. degree from the School of Chemical Engineering, Dalian University of Technology in 2017.Currently, she is pursuing her Ph.D. degree in Prof. Xueqian Kong’s group in the Department of Chemistry, Zhejiang University,Equal contribution;Corresponding author:Yongchao Su Dr.Su has received his B.S.of Chemistry and B.A.of English from Huazhong University of Science and Technology(1999-2003)and M.S.of Physics in State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,the Chinese Academy of Science,with Prof.Feng Deng(2003-2006)in China.He then pursued his Ph.D.of Chemistry at Iowa State University with Prof.Mei Hong(2006-2011),followed by a postdoctoral training at Massachusetts Institute of Technology with Prof.Robert G.Griffin(2011-2014)in the United States.From 2014,Dr.Su is a Principal Scientist in Analytical Research and Development at Merck&Co,Inc.,and an adjunct faculty member in College of Pharmacy at the University of Texas at Austin and Purdue University in the United States,E-mail addresses:yongchao.su@austin.utexas.edu;Corresponding author:Xueqian Kong Dr.Kong graduated with B.S.from University of Science and Technology of China in 2005 and got his Ph.D.in Iowa State University in 2010.In 2010-2013,He spent 3 years as a postdoctoral fellow in University of California Berkeley and Lawrence Berkeley National Laboratory,following Prof.Jeffrey Reimer and Prof.Omar Yaghi.In 2013-2014,he worked as a senior engineer in the Materials Lab of HGST Inc.In 2014,Dr.Kong joined the faculty of the Department of Chemistry in Zhejiang University.He is also the adjunct professor in the Department of Rehabilitation,Sir Run Run Shaw Hospital that is associated with the School of Medicine,Zhejiang University,E-mail addresses:kxq@zju.edu.cn。
