摘要
目的:探讨不同血压控制水平对腹膜透析(peritoneal dialysis,PD)患者残余肾功能(residual renal function,RRF)和心血管事件风险的影响。方法:选取2015年5月至2020年3月池州市人民医院肾内科收治的104例PD患者,随机数表法分成Ⅰ组和Ⅱ组,各52例,Ⅰ组和Ⅱ组血压控制靶目标分别为<140/90 mmHg、<130/80 mmHg,治疗48周。比较两组治疗前后24 h尿量、残肾尿素清除率(Kt/V)、残肾肌酐清除率(creatinine clearance rate,Ccr)、残肾肾小球滤过率(glomerular filtration rate,GFR)、总Kt/V、总Ccr的变化,并记录心血管事件发生情况。结果:两组治疗48周后24 h尿量、残肾Kt/V、残肾Ccr、残肾GFR、总Kt/V、总Ccr与入组时比较均有明显下降,且Ⅱ组治疗48周后上述指标均高于Ⅰ组,差异有统计学意义(P<0.05);Ⅱ组治疗随访48周内心血管事件发生率5.77%,低于Ⅰ组的19.23%,差异有统计学意义(P<0.05)。结论:PD患者血压控制靶目标为<130/80 mmHg,有助于保护RRF,提高透析充分性,降低心血管事件发生风险。
Objective: To investigate the effects of different blood pressure control levels on residual renal function(RRF) and cardiovascular event risk in patients with peritoneal dialysis(PD). Methods: A total of 104 patients with PD admitted to the Department of Nephrology of Chizhou People’s Hospital from May 2015 to March 2020 were randomly divided into group Ⅰ and group Ⅱ, with 52 cases in each group. The targets of blood pressure control in the two groups were <140/90 mmHg and <130/80 mmHg, respectively. The treatment lasted for 48 weeks. The 24 h urine volume, residual renal urea clearance rate(Kt/V), creatinine clearance rate(Ccr), residual renal glomerular filtration rate(GFR), total Kt/V and total Ccr were compared between the two groups before and after treatment, and the occurrence of cardiovascular events was recorded. Results: After 48 weeks of treatment, 24 h urine volume, residual kidney Kt/V, residual kidney Ccr, residual kidney GFR, total Kt/V, total Ccr of the two groups were significantly decreased compared with those before treatment, and the above indexes of group Ⅱ after 48 weeks of treatment were higher than those of group Ⅰ, the difference was statistically significant(P<0.05). The incidence of cardiovascular events in group Ⅱ was 5.77%, which was lower than 19.23% in group Ⅰ, and the difference was statistically significant(P<0.05). Conclusion: The target of blood pressure control in PD patients is less than 130/80 mm Hg, which is helpful to protect RRF, improve dialysis adequacy, and reduce the risk of cardiovascular events.
作者
杨明榴
YANG Mingliu(Department of Nephrology,Chizhou People’s Hospital,Chizhou Anhui 247000,China)
出处
《临床与病理杂志》
CAS
2021年第9期2018-2023,共6页
Journal of Clinical and Pathological Research
关键词
腹膜透析
血压管理
残余肾功能
心血管事件
peritoneal dialysis
blood pressure management
residual renal function
cardiovascular events
作者简介
通信作者:杨明榴,Email:2459776871@qq.com。
