摘要
骨肉瘤是一种恶性的骨肿瘤,好发于年轻人的长骨干骺端,患者5年生存率为60%~70%。骨肉瘤早期即可发生肺转移。15%~20%的患者在首次检查时即可发现肺转移,早期肺转移患者5年生存率低于20%。microRNA是一类长度为19~24核苷酸的非编码小RNA分子,可通过非完全配对的方式与靶基因mRNA结合,引导沉默复合体的形成来降解mRNA或者阻碍其翻译,从而抑制相关蛋白的表达。microRNA-21在多种肿瘤中稳定表达,包括骨肉瘤。本文回顾microRNA-21在骨肉瘤中的作用,为骨肉瘤的临床诊疗和基础研究提供参考。
Osteosarcoma is a malignant bone tumor,which often occurs in the epiphysis of young people.The 5-year sur⁃vival rate of patients with osteosarcoma is 60%-70%.Lung metastasis can be detected at first examination in 15%-20%of pa⁃tients,and 5-year survival rate in patients with early lung metastasis is no more than 20%.MicroRNAs are a class of small noncod⁃ing RNA molecules with 19-24 nucleotides in length that bind to target gene mRNA by incomplete pairing ways.RNA-induced si⁃lencing complex is formed to degrade mRNA or impede its translation,thus inhibiting the expression of related proteins.MicroR⁃NA-21 is stably expressed in a variety of tumors,including osteosarcoma.This study aims to review the role of microRNA-21 in osteosarcoma,in order to provide reference for the diagnosis and treatment of osteosarcoma and basic research.
作者
申振
武壮壮
张龙
吕智
SHEN Zhen;WU Zhuang-zhuang;ZHANG Long;LV Zhi(the Second Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China)
出处
《海南医学院学报》
CAS
2021年第18期1432-1435,1440,共5页
Journal of Hainan Medical University
基金
国家自然科学基金面上项目(81772867)
山西省自然基金面上项目(201801D121325、201801D121215)。
作者简介
申振,男,硕士研究生在读,E-mail:15503616714@163.com;通讯作者:吕智,男,博士,教授,博士生导师,E-mail:zhilv2013@163.com。
