摘要
目的探讨甲状腺癌患者行甲状腺全切除术对血清甲状旁腺激素(iPTH)水平、血清胰岛素样生长因子(IGF-1)水平及预后的影响。方法选取2017年1月至2019年2月由青岛市妇女儿童医院收治的157例甲状腺癌患者为研究对象,采用随机数字法将患者分为研究组(n=80)与对照组(n=77)。研究组患者行甲状腺全切除术,对照组行甲状腺近全切除术治疗。观察两组患者临床疗效、住院指标及血钙、炎症指标、iPTH水平、血清IGF-1和预后情况。结果两组患者并发症发生率、转移率比较,差异均无统计学意义(P>0.05);研究组患者总有效率明显高于对照组(P<0.05);研究组患者住院时间、控制症状时间、复发率均明显低于对照组(P<0.05);两组患者术后血钙、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、iPTH、IGF-1水平均低于术前(P<0.05);研究组患者术后血钙、TNF-α、IL-6、iPTH、IGF-1水平均低于对照组(P<0.05)。结论甲状腺癌患者行甲状腺全切除术可降低其血清iPTH、IGF-1、TNF-α与IL-6及血钙水平,且患者预后良好。
Objective To investigate the effect of total thyroidectomy on serum intact parathyroid hormone(iPTH),serum insulin like growth factor-1(IGF-1)and prognosis in patients with thyroid carcinoma.Methods 157 patients with thyroid carcinoma in Qingdao Women′s and Children′s Hospital from January 2017 to February 2019 were enrolled,and divided into two groups by random number table methods.Study group(n=80)received total thyroidectomy,while control group(n=77)received near-total thyroidectomy.The clinical efficacy,hospitalization indexes,serum calcium,inflammatory indexes,iPTH level,serum IGF-1 and prognosis were compared between two groups.Results The complication rate and metastasis rate showed no significant difference between the two groups(P>0.05).The clinical efficacy of study group was significantly higher than that of control group(P<0.05).The hospitalization time,symptom control time,recurrence rate in the study group were significantly lower than those of control group(P<0.05).The levels of serum calcium,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),iPTH and IGF-1 in two groups after operation were lower than those before operation(P<0.05).The levels of serum calcium,TNF-α,IL-6,iPTH and IGF-1 in the study group were lower than those in the control group(P<0.05).Conclusion Patients with thyroid carcinoma undergoing total thyroidectomy can reduce serum iPTH,IGF-1,TNF-α,IL-6,and blood calcium levels,with good prognosis.
作者
郝坤
郝磊
HAO Kun;HAO Lei(Department of Breast and Thyroid Surgery,Qingdao Women′s and Children′s Hospital,Qingdao,Shandong 266011,China;Department of General Surgery,Qingdao Haici Hospital,Qingdao,Shandong 266000,China)
出处
《国际检验医学杂志》
CAS
2021年第18期2234-2236,2240,共4页
International Journal of Laboratory Medicine
关键词
甲状腺癌
甲状腺全切除术
甲状旁腺激素
胰岛素样生长因子
预后
thyroid carcinoma
total thyroidectomy
intact parathyroid hormone
insulin like growth factor-1
prognosis
作者简介
郝坤,男,医师,主要从事普外相关研究。
