摘要
目的:通过对EGFR、EML4-ALK其中一项基因突变且未经治疗的肺癌患者进行中医证候分析,为中医药结合靶向治疗提供依据。方法:收集348例EGFR基因突变患者及101例EML4-ALK基因突变患者中医四诊信息,分别运用系统聚类分析方法得出中医证候。结果:EGFR基因突变患者中医证型为肺肾阴虚证、痰湿血瘀证、肺脾气虚证;EML4-ALK基因突变患者中医证型为痰热壅肺证、阴虚血瘀证、痰湿蕴肺证、肺肾气虚证。结论:EGFR基因突变患者病性表现为虚实夹杂,以正虚为主;EML4-ALK基因突变患者病性表现为虚实夹杂,以邪实为主。
Objective:To analyze the TCM syndromes of untreated lung cancer patients with EGFR or EML4-ALK gene mutation,to provide clinical references for the TCM combined with targeted therapy.Methods:The four diagnostic methods information of 348 patients with EGFR gene mutation and 101 patients with EML4-ALK gene mutation were collected,and their TCM syndromes were obtained by using the systematic cluster analysis method respectively.Results:The TCM syndromes of EGFR gene mutation patients were Yin deficiency of Lung and Kidney,phlegm-dampness and Blood stasis,and Qi deficiency of Lung and Spleen.The TCM syndromes of patients with EML4-ALK gene mutation were phlegm-heat obstructing Lung,Yin deficiency and Blood stasis,phlegm-dampness accumulating Lung syndrome,and Lung-Kidney Qi deficiency syndrome.Conclusion:The disease of patients with EGFR gene mutation is characterized by intermingled deficiency and excess,mainly by the presence of healthy qi asthenia.Patients with EML4-ALK gene mutation were characterized by the intermingled deficiency and excessiveness,however,mainly by the presence of excessiveness pathogenic factor.
作者
李丹博
崔青荣
周庆伟
LI Danbo;CUI Qingrong;ZHOU Qingwei(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou Henan China 450000)
出处
《中医学报》
CAS
2021年第10期2228-2232,共5页
Acta Chinese Medicine
基金
河南省中医药科学研究专项课题项目(2017ZY 2063)。
关键词
非小细胞肺癌
EGFR
EML4-ALK
基因突变
证候分析
聚类分析
虚实夹杂
non-small cell lung cancer
EGFR
EML4-ALK
gene mutation
syndrome analysis
cluster analysis
intermingled case of deficiency and excessiveness
作者简介
李丹博(1991-),女,河南郑州人,医学硕士,研究方向:中医药防治呼吸系统疾病;通信作者:周庆伟,主任医师,教授,硕士研究生导师。E-mail:zhouqingwei2010@126.com。
