摘要
目的分析血清脂蛋白相关磷脂酶A2(Lp⁃PLA2)和低密度脂蛋白胆固醇(LDL⁃C)/高密度脂蛋白胆固醇(HDL⁃C)比值与急性脑梗死(ACI)患者颈动脉粥样斑块稳定性的关系。方法收集2018年3月至2020年1月本院124例ACI患者临床资料,根据有无斑块及斑块特点分为无斑块组(n=29)、稳定斑块组(n=42)及不稳定斑块组(n=53)。比较3组基线资料及入院后血清Lp⁃PLA2及LDL⁃C/HDL⁃C比值,评估血清Lp⁃PLA2及LDL⁃C/HDL⁃C比值与ACI患者斑块稳定性的关系。结果3组性别、年龄、既往史及肌酐等生化指标比较差异均无统计学意义(P>0.05)。3组梗死灶体积、IMT及血清Lp⁃PLA2、LDL⁃C/HDL⁃C比值比较:不稳定斑块组>稳定斑块组>无斑块组,差异均有统计学意义(P<0.05)。Pearson相关性分析显示ACI患者血清Lp⁃PLA2及LDL⁃C/HDL⁃C比值与梗死灶体积、IMT均呈显著正相关(P<0.05)。ROC曲线分析显示血清Lp⁃PLA2、LDL⁃C/HDL⁃C比值均对ACI颈动脉不稳定斑块具有较高诊断价值(P<0.05),其截断值分别为116.48 ng/mL、3.67,且2项联合检测诊断价值高于单一项,AUC值高达0.931。结论血清Lp⁃PLA2及LDL⁃C/HDL⁃C比值与ACI患者颈动脉粥样硬化斑块的形成及稳定性均相关,对指导临床诊疗有积极作用。
Objective To analyze the relationship between serum lipoprotein⁃related phospholi⁃pase A2(Lp⁃PLA2)and low⁃density lipoprotein cholesterol(LDL⁃C)/high⁃density lipoprotein cholesterol(HDL⁃C)ratio and the stability of carotid atherosclerotic plaques in patients with acute cerebral infarction(ACI).Methods The clinical data of 124 patients with ACI in the hospital from March 2018 to January 2020 were collected.According to the ultrasound examination,the patients were divided into the non⁃plaque group,the stable plaque group and the unstable plaque group.The differences in baseline data and serum Lp⁃PLA2 and LDL⁃C/HDL⁃C ratio after admission were compared among the three groups.The relationship between se⁃rum Lp⁃PLA2 and LDL⁃C/HDL⁃C ratio after admission and plaque stability of patients with ACI was evaluat⁃ed.Results There were no statistically significant differences among the three groups in terms of gender,age,past history,creatinine and other biochemical indicators(P>0.05).The infarct volume,IMT,serum Lp⁃PLA2 and LDL⁃C/HDL⁃C ratio in the three groups were shown as:the unstable plaque group>the stable plaque group>the non⁃plaque group(P<0.05).Pearson correlation analysis showed that serum Lp⁃PLA2 and LDL⁃C/HDL⁃C ratio of patients with ACI were significantly positively correlated with infarct volume and IMT(P<0.05).ROC curve analysis showed that the serum Lp⁃PLA2 and LDL⁃C/HDL⁃C ratio had high diagnostic value for carotid artery unstable plaques in ACI(P<0.05),and their cut⁃off values were 116.48 ng/mL and 3.67 respectively,and the diagnostic value of the two combined detection was higher than that of single detec⁃tion,and the AUC value was up to 0.931.Conclusion Serum Lp⁃PLA2 and LDL⁃C/HDL⁃C ratio are related to the formation and stability of carotid atherosclerotic plaques in patients with ACI,and they play a positive role in guiding clinical diagnosis and treatment.
作者
金纪伟
葛冰磊
杨凤
陈永红
JIN Jiwei;GE Binglei;YANG Feng;CHEN Yonghong(Department of Laboratory Medicine,The People's Hospital of Xuancheng,Xuancheng,Anhui,China,242000)
出处
《分子诊断与治疗杂志》
2021年第8期1281-1284,共4页
Journal of Molecular Diagnostics and Therapy
基金
安徽省科技攻关项目(1801042215)。
作者简介
通信作者:金纪伟,E⁃mail:hnhyjjw@163.com。
