摘要
Estrogen-related receptor gamma(ERRg)is one of three members of the ERR family and remains an orphan,as there are no known natural ligands.ERRg is an inducible transcription factor,and its ligandindependent transcriptional activity is regulated by co-regulator interactions and post-transcriptional modifications.Recent findings from animal models show that ERRg,as a downstream mediator of multiple extracellular signals,plays a key role in coordinating endocrine and metabolic signals,resulting in changes in glucose,alcohol,lipid,and iron metabolism in the liver.Therefore,dysregulation of this receptor contributes to the pathogenesis of metabolic diseases such as hyperglycemia,insulin resistance,and alcoholic liver injury.Interestingly,ERRg is also involved in responses to bacterial infection.These findings establish the importance of ERRg in the endocrine and metabolic control of liver metabolism,and suggest that ERRg may be a promising therapeutic target for metabolic diseases of the liver.
基金
This work was supported by National Creative Research Initiatives Grant(No.20110018305 to H.-S.Choi and National Research Foundation(NRF)No.2018R1D1A1B07043953 to D.-K.Kim)
the NRF funded by the Korean government(Ministry of Science,ICT&Future Planning and Ministry of Education)
also carried out with the support of“Cooperative Research Program for Agriculture Science and Technology Development(No.PJ01280701 to D.-K.Kim)”Rural Development Administration,Republic of Korea.
作者简介
Corresponding author:Hueng-Sik Choi,National Creative Research Initiatives Center for Nuclear Receptor Signals,Hormone Research Center,School of Biological Sciences and Technology,Chonnam National University,Gwangju,Republic of Korea.E-mail address:hsc@chonnam.ac.kr。
