摘要
目的探讨小儿咳喘灵口服液辅助治疗小儿哮喘急性发作期的疗效及对其免疫功能和炎症因子的影响。方法选择2019年1月至2020年1月在台州市中心医院就诊的哮喘急性发作期患儿136例,依据随机数字表法分为观察组和对照组,各68例。对照组予以常规雾化疗法,观察组在此基础上给予小儿咳喘灵口服液治疗。比较两组治疗14天后的疗效;治疗前与治疗14天日间和夜间症状评分、肺功能、免疫功能和炎症因子及不良反应情况。结果观察组治疗14天的总有效率(94.12%)显著高于对照组(77.94%)(χ^(2)=7.403,P<0.05)。两组治疗14天的日间和夜间症状评分均较治疗前低(P<0.05),观察组均较对照组低(t值分别为14.110、16.417,P<0.05)。两组治疗14天的用力肺活量(FVC)、呼吸气流量峰值(PEF)和第1秒用力呼吸值(FEV1)均显著高于治疗前,观察组均显著高于对照组(t值分别为10.237、7.455、7.800,P<0.05)。两组治疗14天的CD3+、CD4+和CD4+/CD8+均显著高于治疗前,观察组均显著高于对照组(t值分别为8.256、9.122、9.049,P<0.05)。两组治疗14天的血清IL-4和IL-13水平均较治疗前低,而IL-5水平较治疗前高;观察组治疗14天的血清IL-4和IL-13水平均较对照组低,而IL-5水平较对照组高,差异均有统计学意义(t值分别为10.798、12.431、14.057,P<0.05)。两组均未见发生明显不良反应。结论小儿咳喘灵口服液在小儿哮喘急性发作期的辅助治疗效果良好,可改善患儿的免疫功能,减轻患儿的炎症反应,且无明显不良反应,用药安全性良好。
Objective To investigate the effect of Xiao′er Kechuanling Koufuye in adjuvant treatment of the acute attack of asthma in children and its influence on children′s immune function and inflammatory factors.Methods A total of 136 children with acute asthma in Taizhou Central Hospital from January 2019 to January 2020 were selected,and they were divided into observation group(n=68)and control group(n=68)according to the random number table method.The control group was treated with conventional nebulization,and the observation group was treated with Xiao′er Kechuanling Koufuye on the basis of the control group.The efficacy of 14 days of treatment was compared between the two groups.The scores of daytime and night symptoms,pulmonary function,immune function and inflammatory factors and adverse reactions were compared between the two groups before and after 14 days of treatment.Results The total effective rate(94.12%)of observation group for 14 days of treatment was significantly higher than the control group(77.94%)(χ^(2)=7.403,P<0.05).After treatment 14 days,the day and night symptom scores of two groups were significantly lower than before treatment(all P<0.05),the scores of daytime and night symptoms in the observation group were significantly lower than control group(t=14.11 and 16.417,respectively,both P<0.05).After treatment 14 days,the forced vital capacity(FVC),peak expiratory flow(PEF)and forced expiratory volume in 1 s(FEV1)of two groups were significantly higher than before treatment,the FVC,PEF and FEV1 of observation group were significantly higher than control group(t=10.237,7.455 and 7.800,respectively,all P<0.05).After treatment 14 d,the CD3+,CD4+and CD4+/CD8+oftwo groups were significantly higher than before treatment,the CD3+,CD4+and CD4+/CD8+of observation group were significantly higher than the control group(t=8.256,9.122 and 9.049,respectively,all P<0.05).After treatment 14 days,the serum interleukin-4(IL-4)and IL-13 of two groups were significantly lower than before treatment,the serum IL-4 and IL-13 of observation group were significantly lower than control group(t=10.798 and 12.431,respectively,both P<0.05),while the IL-5 was significantly higher than before treatment,the IL-5 of observation group was significantly higher than the control group(t=14.051,P<0.05).No obvious adverse reactions occurred in the two groups.Conclusion Xiao′er Kechuanling Koufuye is effective in the adjuvant treatment of acute attack of asthma in children.It can improve the immune function of children and reduce the inflammatory reaction of children.There are no obvious adverse reactions and the medication safety is good.
作者
周燕
吴新
冯伟
朱振华
ZHOU Yan;WU Xin;FENG Wei;ZHU Zhenhua(Department of Pediatrics,Taizhou Central Hospitalfiliated Hospital of Taizhou University,Zhejiang Taizhou318000,China)
出处
《中国妇幼健康研究》
2021年第7期1020-1024,共5页
Chinese Journal of Woman and Child Health Research
基金
2018年浙江省科学技术厅资助项目(项目编号:2018C37108)。
关键词
小儿咳喘灵口服液
小儿哮喘
急性发作期
疗效
免疫功能
炎症因子
Xiao′er Kechuanling Koufuye
infantile asthma
acute attack
curative effect
immune function
inflammatory factors
作者简介
周燕(1982-),女,主治医师,主要从事儿童康复工作;通讯作者:吴新,副主任医师。
