摘要
Chronic obstructive pulmonary disease(COPD),characterized by persistent and not fully reversible airflow restrictions,is currently one of the most widespread chronic lung diseases in the world.The most common symptoms of COPD are cough,expectoration,and exertional dyspnea.Although various strategies have been developed during the last few decades,current medical treatment for COPD only focuses on the relief of symptoms,and the reversal of lung function deterioration and improvement in patient^quality of life are very limited.Consequently,development of novel effective therapeutic strategies for COPD is urgently needed.Stem cells were known to differentiate into a variety of cell types and used to regenerate lung parenchyma and airway structures.Stem cell therapy is a promising therapeutic strategy that has the potential to restore the lung function and improve the quality of life in patients with COPD.This review summarizes the current state of knowledge regarding the clinical research on the treatment of COPD with mesenchymal stem cells(MSCs)and aims to update the understanding of the role of MSCs in COPD treatment,which may be helpful for developing effective therapeutic strategies in clinical settings.
基金
supported by grants from the National Key Research and Development Program of China(No.2018YFC1313602)
Major International(Regional)Joint Research Project(No.81820108001)
National Natural Science Foundation of China(No.81670029)
Jiangsu Key Principal Investigator of Medicine(No.ZDRCA2016018)
Nanjing Key Project of Science and Technology(No.2019060002)(to L.Zhou).
作者简介
Correspondence to:Prof.Wei-Ning Xiong,Department of Pulmonary and Critical Care Medicine,Shanghai Ninth People's Hospital,Shanghai Jiaotong University School of Medicine,639 Zhizaoju Road,Shanghai 200011,China,E-Mail:xiongdoctor@qq.com;Prof.Linfu Zhou,Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital,Nanjing Medical University,300 Guangzhou Road,Nanjing,Jiangsu 210029,China,E-Mail:lfzhou@njmu.edu.cn。
