摘要
碳青霉烯类耐药肺炎克雷伯菌(CRKP)使感染患者的病死率居高不下。如何应对CRKP是临床亟待解决的问题,对CRKP开展耐药性机制研究势在必行。而双组分系统(TCSs)与多种细菌耐药性的形成有关,故TCSs可望成为CRKP的重要治疗靶点。因此,本文从肺炎克雷伯菌对碳青霉烯类耐药的常见机制、TCSs的耐药研究进展以及肺炎克雷伯菌与TCSs的关系等方面,对TCSs调控肺炎克雷伯菌对碳青霉烯耐药的机制进行综述,以期为日后的研究提供思路,为临床诊疗提供参考依据。
Carbapenem-resistant Klebsiella pneumoniae(CRKP)leads to high mortality of infected patients.How to deal with CRKP is an urgent problem in clinical practice,and it is imperative to carry out researchon carbapenem resistance mechanism of CRKP.The two-component systems(TCSs)areassociated with the development of drug resistance in a variety of bacteria,and TCSs were expected to be important therapeutic targets for CRKP.Therefore,this article reviewed the mechanisms of TCSs in the regulation of CRKP from the following several aspects:common mechanisms of carbapenem resistance of CRKP,research progress in drug resistance of TCSs,relationships between Klebsiella pneumoniae and TCSs,and so on.It may provide some research ideas for future research and the references for clinical diagnosis and treatment.
作者
陈朝彦
秦志丹
蒋良艳
汤展宏
Chen Zhaoyan;Qin Zhidan;Jiang Liangyan;Tang Zhanhong(Department of Intensive Care Unit,First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China)
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2021年第6期761-764,共4页
Chinese Critical Care Medicine
基金
国家自然科学基金(81960342)
广西医科大学第一附属医院第三批医院优秀医学英才计划项目(XK2019025)。
关键词
肺炎克雷伯菌
碳青霉烯耐药
双组分系统
研究进展
Klebsiella pneumoniae
Carbapenem resistance
Two-component system
Research progress
作者简介
通信作者:汤展宏,Email:tangzhanhong139@sina.com。
