摘要
2013年春,我国首次出现人感染H7N9亚型禽流感疫情,对家禽养殖和公众健康均产生了严重危害,并且在第5波流行期又演变出血凝素(hemagglutinin,HA)蛋白裂解位点处存在插入突变的高致病性禽流感病毒株。HA作为A型流感病毒表面表达丰度最高的糖蛋白,在介导病毒与宿主细胞表面受体的结合、促进病毒囊膜与细胞膜的融合、刺激机体产生中和抗体等方面具有至关重要的作用。本文围绕H7N9病毒,简要综述了HA蛋白的结构与功能,及其关键功能氨基酸位点变异影响病毒生物学特性的研究进展,以期为深入解析HA蛋白在H7N9病毒感染致病中的作用提供重要参考。
In the spring of 2013,human infections with H7N9 subtype avian influenza emerged in China,posing serious threats to both poultry farming and public health.Additionally,highly pathogenic H7N9 variants with insertional mutation at the cleavage site of hemagglutinin(HA)protein yet evolved during the fifth epidemic wave.As the most abundantly expressed glycoprotein on the surface of influenza A virus,HA protein plays crucial roles in the viral lifecycle such as mediating the linkage between virus and host cell surface receptors,promoting the fusion between viral envelope and cell membrane,and stimulating the production of neutralizing antibodies.In this review,we briefly summarized the structure and function of HA protein,and the research progress of functional amino acid variations effecting on H7N9 biological properties,in order to provide important reference for in-depth analysis of the role of HA protein in H7N9 infection and pathogenesis.
作者
严雅瑶
顾敏
刘秀梵
YAN Yayao;GU Min;LIU Xiufan(Key Laboratory of Animal Infectious Diseases of Ministry of Agriculture, Yangzhou University, Yangzhou 225009, China;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China;Jiangsu Key Laboratory of Zoonoses, Yangzhou University, Yangzhou 225009, China)
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2021年第8期2093-2106,共14页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
国家自然科学基金项目(32072892)
现代农业产业技术体系专项(CARS-40)
江苏高校优势学科建设工程资助项目(PAPD)
江苏高校“青蓝工程”
扬州大学“高端人才支持计划”。
作者简介
严雅瑶(1997-),女,江苏南通人,硕士生,主要从事禽流感病毒致病机制研究,E-mail:1425497758@qq.com;通信作者:顾敏,主要从事动物流感病毒研究,E-mail:gumin@yzu.edu.cn,Tel:0514-87972247。
