摘要
目的:探讨孕妇生殖道B族链球菌(GBS)感染情况分析及对母婴结局的影响。方法:选取2019年9月至2020年9月在我院产检且住院分娩的妊娠孕妇作为研究对象,将其中50例生殖道B族链球菌感染孕妇纳入观察组,并将同期在本院产检且住院分娩的50例未感染GBS的正常妊娠孕妇纳入对照组。对观察组50例生殖道B族链球菌感染孕妇的GBS阳性菌株进行药物敏感度分析研究,并记录观察组和对照组的妊娠结局进行比较。结果:①常用抗菌药物敏感度分析试验显示,分离的50株B族链球菌菌株对克拉霉素、莫西沙星、红霉素和四环素高比率耐药,对氨苄青霉素、青霉素G、头孢曲松、头孢吡肟、万古霉素、喹奴普汀/达福普汀高度敏感。②观察组早产、宫内感染、胎膜早破、产褥感染、产后出血、高胆红素血症、肺炎、窒息、黄疸发生率显著高于对照组,差异均具有统计学意义(P<0.05)。结论:GBS感染会对妊娠结局造成不良影响,可能会增加早产等孕妇不良结局以及高胆红素血症等新生儿不良结局的发生。定期孕检、加强生殖道B族链球菌感染高危人群早期监测,有利于降低孕妇生殖道B族链球菌感染率,大幅度改善妊娠结局。
Objective:To investigate the infection of group B streptococcus(GBS)in reproductive tract of pregnant women and its influence on maternal and infant outcomes.Methods:From September 2019 to September 2020,50 pregnant women with group B streptococcus infection in reproductive tract were included in the observation group,and 50 normal pregnant women without GBS infection were included in the control group.The drug sensitivity of GBS positive strains of 50 pregnant women with group B streptococcus infection in the observation group was analyzed,and the pregnancy outcomes of the observation group and the control group were recorded for comparison.Results:①The sensitivity analysis of commonly used antibiotics showed that 50 strains of group B Streptococcus were highly resistant to clarithromycin,moxifloxacin,erythromycin and tetracycline,and highly sensitive to ampicillin,penicillin G,ceftriaxone,cefepime,vancomycin and quinupristin/daptin.②The incidences of preterm birth,intrauterine infection,premature rupture of membranes,puerperal infection,postpartum hemorrhage,hyperbilirubinemia,pneumonia,asphyxia and jaundice in the observation group were significantly higher than those in the control group,with statistical significance(P<0.05).Conclusion:GBS infection can cause adverse effects on pregnancy outcomes,which may increase the incidence of adverse outcomes such as premature delivery and neonatal adverse outcomes such as hyperbilirubinemia.Regular pregnancy examination and early monitoring of high-risk groups of group B streptococcus infection in reproductive tract are helpful to reduce the infection rate of group B streptococcus in reproductive tract of pregnant women and greatly improve the pregnancy outcome.
作者
黄伟丽
陈锐芳
Huang Weili(Department of Laboratory,Yunfu Maternaland Child Health Hospital,Yunfu Guangdong 527300)
出处
《黑龙江医药》
CAS
2021年第4期781-783,共3页
Heilongjiang Medicine journal
基金
云浮市医药卫生科研项目(编号:2016B31)。
关键词
生殖道感染
孕妇
B族链球菌
感染情况
妊娠结局
Reproductive Tract Infection
Pregnant Women
Group B Streptococcus
Infection
Pregnancy Outcome
