摘要
目的探讨帕利哌酮缓释片联合奥氮平对精神分裂症患者血清脑源性神经营养因子(BDNF)、神经生长因子(NGF)及对代谢综合征(MS)影响。方法选择2017年5月至2019年5月期间北京回龙观医院收治的精神分裂症患者83例,依据随机表法分为联合组42例与对照组41例。对照组患者给予奥氮平治疗,联合组在对照组基础上结合帕利哌酮缓释片治疗。2组疗程均为8周。比较2组治疗疗效,治疗前后阳性和阴性症状量表(PANSS)评分、BDNF、NGF水平变化及MS发生情况。结果联合组精神分裂症患者治疗8周总有效率(90.48%)高于对照组(70.73%,P<0.05)。联合组精神分裂症患者治疗8周PANSS总分[(38.72±3.61)分]低于对照组[(45.93±4.25)分,P<0.05]。联合组精神分裂症患者治疗8周血清BDNF[(3.61±0.18)ng/mL]和NGF[(42.31±2.08)pg/mL]高于对照组[(3.09±0.23)ng/mL、(38.03±2.24)pg/mL,P<0.05]。联合组精神分裂症患者MS发生率(28.57%)低于对照组(51.22%,P<0.05)。结论帕利哌酮缓释片联合奥氮平对精神分裂症患者效果良好,其原因可能与上调BDNF、NGF水平相关,可降低MS发生率。
Objective To investigate the effect of sustained-release tablets of parlipidone combined with olanzapine on the levels of brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF)and metabolic syndrome(MS)in patients with schizophrenia.Methods 83 schizophrenics admitted to our hospital from May 2017 to may 2019 were randomly divided into a combined group(42 cases)and control group(41 cases).The patients in the control group were treated with olanzapine,while the patients in the combined group were treated with palipexone sustained-release tablets on the basis of the control group.The course of treatment in both groups was 8 weeks.The therapeutic effect,PANSS score,BDNF,NGF levels before and after treatment were comparable between the two groups.Results The combined group effective(90.48%)was higher control group(70.73%,P<0.05).After treatment of 8 weeks,the combined group PANSS total score(38.72±3.61)was lower control group(45.93±4.25,P<0.05).After treatment of 8 weeks,the combined group serum BDNF(3.61±0.18)ng/mL and NGF(42.31±2.08)pg/mL were higher control group(3.09±0.23)ng/mL and(38.03±2.24)pg/mL(P<0.05).The combined group incidence of MS(28.57%)was lower control group(51.22%,P<0.05).Conclusion The effect of pallidone sustained release tablets combined with olanzapine on schizophrenia is good,it may be related to the up regulation of BDNF and NGF,can reduce the incidence of MS.
作者
李晞
时丽
姚尚武
陈大春
LI Xi;SHI Li;YAO Shang-wu;CHEN Da-chun(Department of Laboratory Medicine,Beijing Huilongguan Hospital,Beijing 100096,China;Department of Psychiatry,Beijing Huilongguan Hospital,Beijing 100096,China)
出处
《东南国防医药》
2021年第4期368-371,共4页
Military Medical Journal of Southeast China
关键词
帕利哌酮缓释片
奥氮平
精神分裂症
代谢综合征
脑源性神经营养因子
神经生长因子
sustained release tablets of pariprasidone
olanzapine
schizophrenia
metabolic syndrome
brain-derived neurotrophic factor
nerve growth factor
作者简介
通信作者:陈大春,E-mail:cdc1963@sina.com。
