摘要
目的:探讨血清学检测在早期胃癌筛查及早期治疗效果评价中的应用价值及临床意义。方法:选取2019年4月-2020年4月于本院消化内科就诊的120例高风险早期胃癌患者为研究对象,另选取同期体检健康人员50例为对照组。根据组织病理学检测结果将120例高风险早期胃癌患者分为早期胃癌组59例以及良性胃病组61例。采集所有研究对象外周静脉血并对其进行胃蛋白酶原(pepsinogen,PG)、胃泌素17(gastrin-17,G-17)血清学检测,比较不同分组血清学的检测结果。结果:三组PGⅠ、PGⅡ、G-17比较,差异均有统计学意义(P<0.05)。早期胃癌组PGⅠ明显低于对照组、良性胃病组,PGⅡ、G-17水平均明显高于对照组和良性胃病组,差异均有统计学意义(P<0.05)。良性胃病组PGⅠ低于对照组,PGⅡ、G-17水平均高于对照组,差异均有统计学意义(P<0.05)。59例早期胃癌患者中有45例接受内镜下手术治疗(内镜手术治疗组),术后3个月评价RR为88.89%,CBR为97.78%,另14例接受常规药物保守治疗(保守治疗组),治疗3个月评价RR为42.86%,CBR为92.86%,内镜手术治疗组RR明显高于保守治疗组(P<0.05),但两组CBR比较,差异无统计学意义(P>0.05)。治疗前,内镜手术治疗组与保守治疗组PGⅠ、PGⅡ、G-17水平比较,差异均无统计学意义(P>0.05);治疗后,内镜手术治疗组PGⅡ、G-17水平均明显低于保守治疗组,PGⅠ水平明显高于保守治疗组,差异均有统计学意义(P<0.05)。结论:检测PG、G-17水平对早期胃癌筛查意义较大,并在评估早期胃癌治疗效果方面具有一定作用,具有临床应用及推广价值。
Objective:To explore the application value and clinical significance of serological detection in early gastric cancer screening and evaluation of early treatment effect.Method:A total of 120 patients with highrisk early gastric cancer admitted to the Department of Gastroenterology of our hospital from April 2019 to April 2020 were selected as the research subjects,and 50 healthy persons examined during the same period were selected as the control group.A total of 120 high-risk patients with early gastric cancer were divided into early gastric cancer group(n=59)and benign gastric disease group(n=61)according to the results of histomathological examination.Peripheral venous blood of all subjects was collected and pepsinogen(PG)and gastrin-17(G-17)serological tests were performed.Serological test results of different groups were compared.Result:Comparison of three groups PGⅠ,PGⅡand G-17,the differences were statistically significant(P<0.05).PGⅠin early gastric cancer group was significantly lower than those in the control group and the benign gastric disease group,PGⅡand G-17 levels were significantly higher than those in the control group and the benign gastric disease group,the differences were statistically significant(P<0.05).PGⅠin benign gastric disease group was lower than that in the control group,PGⅡand G-17 levels were higher than those in the control group,the differences were statistically significant(P<0.05).Among 59 patients with early gastric cancer,45 patients received endoscopic surgery(the endoscopic surgery group),with RR of 88.89%and CBR of 97.78%3 months after surgery,and the other 14 patients received conservative treatment with conventional drugs(the conservative treatment group),with RR of 42.86%and CBR of 92.86%3 months after treatment,the RR of the endoscopic surgery group was significantly higher than that of the conservative treatment group(P<0.05),but there was no significant difference in CBR between two groups(P>0.05).Before treatment,there were no significant differences in PGⅠ,PGⅡand G-17 levels between the endoscopic surgery group and the conservative treatment group(P>0.05).After treatment,PGⅡand G-17 levels in the endoscopic surgery group were significantly lower than those in the conservative treatment group,PGⅠlevel was significantly higher than that of the conservative treatment group,the differences were statistically significant(P<0.05).Conclusion:The detections of PG and G-17 levels are great significance for early gastric cancer screening and play a certain role in the evaluation of treatment effect of early gastric cancer,which has clinical application and promotion value.
作者
陈绮丹
CHEN Qidan(Guangzhou Panyu Central Hospital,Guangzhou 511400,China)
出处
《中国医学创新》
CAS
2021年第18期72-76,共5页
Medical Innovation of China
作者简介
通信作者:陈绮丹。
