摘要
结节性多动脉炎(polyarteritis nodosa,PAN)作为一类累及中、小动脉全层的坏死性血管炎(necrotizing vasculitis),其发病机制尚不明确,存在病程长、诊断困难的问题,导致患者病情无法及时得到有效控制,最终可能发生重要脏器受侵,严重影响其生活质量,甚至威胁生命。本文结合既往研究,围绕PAN发病机制研究进展作一综述,旨在为临床诊治提供一定参考。
Polyarteritis nodosa(PAN) is a kind of necrotizing vasculitis involving the whole layer of the middle and small arteries.Its pathogenesis is not clear,and it has the problems of long course and difficult diagnosis.As a result,the patient’s condition can not be effectively controlled in time,and eventually the invasion of important organs may occur,which seriously affects the quality of life,even life-threatening.In this paper,we reviewed the research progress on the pathogenesis of PAN in order to provide some reference for clinical diagnosis and treatment.
作者
付敏
秦蕾
王慧杰
夏光涛
FU Min;QIN Lei;WANG Huijie;XIA Guangtao(Department of Rheumatology and Immunology,Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,Shandong Province,China)
出处
《世界临床药物》
2021年第6期429-432,共4页
World Clinical Drug
基金
国家自然科学基金(82001744)
山东省重点研发项目(2017GSF218083)
济南市临床医学科技创新计划(202019051)。
作者简介
付敏,副主任医师,研究方向:风湿免疫相关疾病诊治;通信作者:夏光涛,副主任医师,研究方向:风湿免疫相关疾病诊治。
