摘要
目的探讨耐多药肺结核患者高分辨率计算机断层扫描(CT)征象与调节性T淋巴细胞(Treg)的相关性。方法将本院收治的73例耐多药肺结核患者和92例非耐药肺结核患者分别记为研究组和对照组。比较两组的高分辨率CT征象、Treg比率;制作受试者工作特征曲线(ROC),分析Treg比率对耐多药肺结核的诊断效能;比较不同Treg比率耐多药肺结核患者高分辨率CT征象。结果研究组高分辨率CT征象中钙化、纤维化、肺内散播结节、肺损伤、支气管扩张、胸膜增厚、纵隔淋巴结肿大及增殖的患者占比及Treg比率均高于对照组(P<0.05)。由ROC可知,Treg比率诊断耐多药肺结核的最佳截断点为5.25%,灵敏度、特异度及曲线下面积(AUC)分别为76.71%、64.13%、0.733。Treg比率>5.25%的患者高分辨率CT征象中纤维化、肺损伤、胸膜增厚及增殖占比均高于Treg比率≤5.25%的患者(P<0.05)。结论耐多药肺结核患者高分辨率CT征象与Treg比率有关,Treg比率越高,患者高分辨率CT征象中纤维化、肺损伤、胸膜增厚及增殖占比越高,Treg比率可作为反映耐多药肺结核患者肺部病变状况的重要参考指标。
Objective To investigate the correlation between high-resolution computed tomography(CT)signs and regulatory T lymphocytes(Treg)in patients with multidrug-resistant pulmonary tuberculosis.Methods A total of 73 patients with multidrug-resistance pulmonary tuberculosis and 92 patients with non-drug-resistant pulmonary tuberculosis admitted in our hospital were seted as study group and control group,respectively.The high-resolution CT signs and Treg ratio of the two groups were compared;a receiver operating characteristic curve(ROC)was made to analyze the diagnostic efficacy of the Treg ratio for multidrug-resistant pulmonary tuberculosis;the high-resolution CT signs of multidrug-resistance pulmonary tuberculosis patients with different Treg ratios were compared.Results The proportions of patients with calcification,fibrosis,disseminated nodules in the lung,lung injury,bronchiectasis,thickening of the pleura,mediastinal lymph node enlargement,proliferation in the high-resolution CT signs and Treg ratio of the study group were higher than those of the control group(P<0.05).According to ROC,the best cut-off point of Treg ratio for the diagnosis of multidrug-resistance pulmonary tuberculosis was 5.25%,and the sensitivity,specificity and area under the curve(AUC)were 76.71%,64.13%,and 0.733,respectively.The proportions of fibrosis,lung injury,thickening of the pleura and proliferation in high-resolution CT signs of Treg ratio>5.25%patients were higher than those of Treg ratio≤5.25%patients(P<0.05).Conclusion The high-resolution CT signs of patients with multidrug-resistant pulmonary tuberculosis are related to the Treg ratio,the higher the Treg ratio,the higher the proportion of fibrosis,lung injury,thickening of the pleura and proliferation in the high-resolution CT signs of patients.Treg ratio can be used as an important reference index to reflect the status of pulmonary lesions in patients with multidrug-resistance pulmonary tuberculosis.
作者
王立
贾斐
高瑜
李永波
陈晓辉
WANG Li;JIA Fei;GAO Yu;LI Yongbo;CHEN Xiaohui(Image Center,Tuberculosis Hospital of Shaanxi Province,Xi'an 710100,China;No.7 Internal Medicine Department,Tuberculosis Hospital of Shaanxi Province,Xi'an 710100,China;No.4 Internal Medicine Department,Tuberculosis Hospital of Shaanxi Province,Xi'an 710100,China)
出处
《临床医学研究与实践》
2021年第21期122-124,共3页
Clinical Research and Practice
基金
陕西省重点研发计划项目(No.2020SF-105)。
关键词
耐多药肺结核
计算机断层扫描
征象
调节性T淋巴细胞
multidrug-resistance pulmonary tuberculosis
computed tomography
signs
regulatory T lymphocytes
作者简介
王立(1983-),男,汉族,陕西西安人,主治医师。研究方向:结核影像;通讯作者:贾斐,E-mail:jiafei198842@163.com。
