摘要
目的:探讨抗感染药物对孕妇在妊娠期发生轻症细菌感染性疾病时的治疗效果和母婴健康的影响。方法:选择2019年1月至2020年1月,承德市中心医院收治的于妊娠期发生轻症细菌感染性疾病的患者120例,所有患者均实施正常产检。按简单随机分组,分为观察组和对照组,各60例,观察组孕期合并轻症细菌感染后使用抗生素治疗,而对照组合并轻症细菌感染后不使用抗生素治疗,比较两组患者的感染部位,统计观察组抗生素使用情况。比较抗生素的使用与否对两组孕妇整个孕期的影响情况,如妊娠不良情况(早产、胎膜早破、流产等),同时对两组患者的末次B超结果(胎儿双顶径、股骨长度、出生体重、出生胎龄)进行对比分析。结果:两组患者在消化系统、呼吸系统、泌尿系统、生殖系统分布较为一致,无统计学差异(P>0.05);观察组患者中应用的抗生素类型如下:第三代头孢菌素类30例(50.00%)、青霉素类18例(30.00%)、大环内酯类6例(10.00%)、林可霉素类4例(6.67%)、四环素类抗生素2例(3.33%)。用量最多的是第三代头孢菌素。观察组不良妊娠(早产、胎膜早破、流产等)出现的比例为8.33%(5/60),明显低于对照组(35.00%,21/60),差异有统计学意义(χ^(2)=12.570,P<0.01);与对照组比较,观察组临产前最后一次B超检查,双顶径长度、股骨长度等发育指标以及胎儿出生体质量、显著性升高,有统计学差异(P<0.05)。结论:妊娠期间发生轻症细菌感染性疾病,合理的运用抗生素能够降低不良妊娠发生率,对改善分娩结局具有重要意义。
Objective:To explore the effects of anti-infective drugs on the treatment of mild bacterial infections in pregnant women and the health of mothers and babies.Methods:From January 2019 to January 2020,120 patients with mild bacterial infections during pregnancy who were admitted to Chengde Central Hospital were selected.All patients underwent normal obstetric examinations.According to simple random grouping,they were divided into observation group and control group,each with 60 cases.The observation group was treated with antibiotics after a mild bacterial infection during pregnancy,while the control group was not treated with antibiotics after a mild bacterial infection.The infection sites of the two groups of patients were compared,and the antibiotic usage in the observation group was counted.Compare the use of antibiotics on the impact of the two groups of pregnant women during the entire pregnancy,such as poor pregnancy(premature delivery,premature rupture of membranes,abortion,etc.),and at the same time the last B-ultrasound results(fetal double parietal diameter,femoral length,Birth weight,birth gestational age)for comparative analysis.Results:The distribution of the two groups of patients in the digestive system,respiratory system,urinary system,and reproductive system was relatively consistent,and there was no statistical difference(P>0.05);the types of antibiotics used in the observation group were as follows:30 third-generation cephalosporins(50.00%),18 cases of penicillins(30.00%),6 cases of macrolides(10.00%),4 cases of lincomycins(6.67%),and 2 cases of tetracycline antibiotics(3.33%).The most used is the third-generation cephalosporin.The incidence of adverse pregnancy(premature delivery,premature rupture of membranes,miscarriage,etc.)in the observation group was 8.33%(5/60),which was significantly lower than that of the control group(35.00%,21/60),and the difference was statistically significant(χ^(2)=12.570),P<0.01);Compared with the control group,the observation group’s last B-ultrasound examination before labor,the developmental indicators such as the length of the double parietal diameter and the length of the femur,and the birth weight of the fetus were significantly increased,with statistical differences(P<0.05).Conclusion:Mild bacterial infections occur during pregnancy.Reasonable use of antibiotics can reduce the incidence of adverse pregnancy and is of great significance for improving the outcome of childbirth.
作者
姚淑慧
孟爱霞
YAO Shuhui(Chengde Applied Vocational Technical College,Hebei Chengde 067000,China)
出处
《河北医学》
CAS
2021年第7期1197-1200,共4页
Hebei Medicine
基金
河北省承德市科学技术研究与发展计划项目,(编号:202006A006)。
关键词
妊娠
轻症细菌感染
抗生素
妊娠结局
影响
Pregnancy
Combined with mild infection
Antibiotics
Pregnancy outcome
Influence
作者简介
通讯作者:孟爱霞。
