摘要
目的探究血液透析联合血液灌流治疗尿毒症脑病(UE)患者的效果及其对毒素清除水平、神经功能及血清神经因子的影响。方法选取我院收治的107例UE患者,根据随机数字表法分组。对照组53例给予单纯血液透析(HD)治疗,观察组54例给予血液透析(HD)联合血液灌流(HP)治疗,对比两组患者疗效。结果治疗后观察组尿素氮(BUN)、血肌酐(Scr)、全段甲状旁腺激素(iPTH)、β2-微球蛋白(β2-MG)、神经功能缺损(NIHSS)和不良事件发生率均低于对照组,格拉斯哥昏迷评分(GCS)、脑源性神经营养因子(BDNF)、神经肽Y(NPY)和总有效率高于对照组(P<0.05)。结论HD联合HP可促进UE患者神经功能恢复,提高毒素清除水平,提升临床疗效,安全性高。
Objective To explore the effect of hemodialysis combined with hemoperfusion in the treatment of patients with uremic encephalopathy(UE)and its effect on toxin clearance,neurological function and serum neural factors.Methods A total of 107 UE patients in our department were selected and grouped according to the random number table method.53 cases in the control group were treated with hemodialysis(HD),and 54 cases in the observation group were treated with hemodialysis(HD)combined with hemoperfusion(HP).The treatment effect of two groups were compared.Results After treatment,the level of BUN,Scr,iPTH,β2-MG,NIHSS,and the incidence of adverse events in the observation group were lower than those in the control group,and the levels of GCS,BDNF,NPY and total effective rates in the observation group were higher than those in the control group(P<0.05).Conclusion HD combined with HP can promote the recovery of nerve function,promote the level of toxin removal,and further improve the clinical efficacy and safety of patients with UE.
作者
陈玉灵
申鹏
孙丹丹
Chen Yuling;Shen Peng;Sun Dandan(People’s Hospital of Hebi City,Hebi 458030,China)
出处
《国际移植与血液净化杂志》
2021年第3期19-22,共4页
International Journal of Transplantation and Hemopurification
关键词
血液透析
血液灌流
尿毒症脑病
Hemodialysis
Hemoperfusion
Uremic encephalopathy
作者简介
通信作者:陈玉灵,Email:xiezthb@163.com。
