摘要
目的观察分析垂体后叶素联合卡前列素氨丁三醇和缩宫素治疗胎盘早剥产后大出血的临床疗效。方法选取2019年1月至2020年5月收治的胎盘早剥产后大出血患者82例,按随机数字表法分为两组,各41例。参照组采用卡前列素氨丁三醇和缩宫素治疗,联合组在参照组基础上联合垂体后叶素治疗。比较两组治疗前后凝血功指标变化情况、第三产程时间、止血时间、产后出血量和不良情况发生率。结果治疗前,两组TT、APTT和FIB等凝血功能指标水平比较差异无统计学意义,治疗后,联合组TT和APTT水平均明显短于参照组,FIB指标水明显低于参照组,差异有统计学意义(P<0.05)。联合组第三产程时间、止血时间均明显短于参照组,差异有统计学意义(P<0.05);产后15 min及2、24 h出血量均显著少于参照组,差异有统计学意义(P<0.05)。联合组不良情况发生率均显著低于参照组,差异有统计学意义(P<0.05)。结论在胎盘早剥产后大出血的治疗中采用垂体后叶素联合卡前列素氨丁三醇和缩宫素效果显著,有利于改善凝血功能状况,从而加速产程进展,缩短止血时间,减少产后出血量,降低不良情况发生率,进而确保母婴安全,值得临床推广应用。
Objective To observe and analyze the clinical effect of pituitrin combined with carboprost tromethamine and oxytocin in the treatment of postpartum hemorrhage after placental abruption.Methods From January 2019 to May 2020,82 patients with postpartum hemorrhage after placental abruption were selected and they were divided into two groups according to the random number table method,with 41 cases in each group.The reference group was treated with carboprost tromethamine and oxytocin,and the combined group was treated with pituitrin on the basis of the reference group.The changes of coagulation function indexes before and after treatment,as well as the third stage of laborthe third labor process time,hemostasis time,postpartum hemorrhage volume and incidence of adverse events were compared between the two groups.Results Before treatment,there was no significant difference in TT,APTT,FIB and other coagulation function indexes between the two groups.After treatment,TT and APTT levels in the combined group were significantly shorter than those in the reference group,and FIB index water was significantly lower than that in the reference group,the difference was statistically significant(P<0.05);the third stage of laborthe third labor process time and hemostasis time in the combined group were significantly shorter than those in the reference group,the difference was statistically significant(P<0.05).The blood loss in 15 min,2 h and 24 h after delivery in the reference group was significantly less than those in the reference group,the difference was statistically significant(P<0.05).The incidence of adverse events in the combined group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion In the treatment of postpartum hemorrhage after placental abruption,pituitrin combined with carboprost tromethamine and oxytocin is more effective,which can improve the coagulation function,accelerate the progress of labor,shorten the hemostasis time,reduce the amount of postpartum hemorrhage,and reduce the incidence of adverse conditions,so as to ensure the safety of mother and baby,which can be widely used in clinical treatment.
作者
朱屹峰
陈丽红
朱屹华
ZHU Yifeng;CHEN Lihong;ZHU Yihua(Department of Obstetrics and Gynecology,Huludao Central Hospital,Huludao,Liaoning,125001,China)
出处
《当代医学》
2021年第21期26-29,共4页
Contemporary Medicine
