摘要
De ar Editor,Memory defect and neuronal loss are both hallmarks of Alzheimer’s disease(AD).According to theβ-amyloid(Aβ)hypothesis,persistent accumulation of Aβpeptides,including different aggrega-tion forms,induces neuronal dysfunction and death of neurons.However,one major difference between these two symptoms is that memory defect usually starts in the early stage of AD while neu-rodegeneration occurs in the advanced stage.Previous studies have reported that the activities of diverse protein fac-tors and their related signaling pathways are associated with the Aβ-induced tox-icities(Small et al.,2001).But until now,it is still an open question that whether memory defect and neurodegeneration share the same mechanism.Answering this question will be of great help for fu-ture drug development and therapy.
作者简介
Correspondence:Lei Wang,wanglei@mail.buct.edu.cn,These authors contributed equally to the work;Correspondence:Yi Zhong,zhongyi@cshl.org。
