摘要
In recent years,metal peroxide(MO_(2))such as CaO_(2) has received more and more attention in cancer treatment.MO_(2) is readily decompose to release metal ions and hydrogen peroxide in the acidic tumor microenvironment(TME),resulting metal ions overloading,decreased acidity and elevated oxidative stress in TME.All of these changes making MO_(2) an excellent tumor therapeutic agent.Moreover,by combining MO_(2) with photosensitizers,enzymes or Fenton reagents,MO_(2) can assist and promote various tumor therapies such as photodynamic therapy and chemodynamic therapy.In this review,the synthesis and modification methods of MO_(2) are introduced,and the representative studies of MO_(2)-based tumor monotherapy and combination therapy are discussed in detail.Finally,the current challenges and prospects of MO_(2) in the field of tumor therapy are emphasized to promote the development of MO_(2)-based cancer treatment.
基金
This work is financially supported by the National Key R&D Program of China(2018YFA0704000)
the National Natural Science Foundation of China(21807074,51802202,31900945,82071985)
Shenzhen Science and Technology Program(KQTD20190929172538530,JCYJ20180507182413022,JCYJ20170412111100742)
the Guangdong Province Natural Science Foundation of PhD Start-up Fund(2018A030310574 and 2018A030310566)
the Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project(2018B030308003)
the Fundamental Research Funds for the Central Universities(2020CDJQY-A060).
作者简介
Corresponding author:Peng Huang,E-mail address:peng.huang@szu.edu.cn;Jin He,These authors contributed equally to this work;Lian-Hua Fu,These authors contributed equally to this work。
