摘要
Cardiovascular diseases(CVDs)are among the leading causes of mortality and morbidity worldwide.Nitric oxide(NO)is a signalling molecule that plays a vital role in protecting and regulating cardiovascular function and homeostasis.Despite several successful outcomes of exogenous supplementation of NO for cardiovascular disease therapy,a great challenge lies in controlled and long-term delivery due to the short half-life and instability of NO.Recently,increasing attention has been paid to the in situ conversion of endogenous NO donors catalysed by functional surfaces.Based on bioinspired and biomimicking strategies,a series of surface functionalization methods for cardiovascular stents has been successfully developed.By further combining NO catalysis with other biofunctionalities,improved endothelium healing and long-term patency can be anticipated.
基金
This study was supported by grants from the National Key R&D Program of China(2018YFE0200503)
National Natural Science Foundation of China(81925021 and 81871500)
Natural Science Foundation of Tianjin(18JCJQJC46900).
作者简介
Corresponding author:Zhikun Guo,Zhengzhou Cardiovascular Hospital and 7th People’s Hospital of Zhengzhou,Zhengzhou,Henan Province,China,E-mail addresses:gzk@xxmu.edu.cn;Corresponding author:Qiang Zhao,Zhengzhou Cardiovascular Hospital and 7th People’s Hospital of Zhengzhou,Zhengzhou,Henan Province,China.E-mail addresses:qiangzhao@nankai.edu.cn.
