摘要
Combination chemotherapy is widely exploited to overcome multidrug resistance(MDR) and enhance the therapeutic effect of anti-tumor agents clinically. The traditional combination regimens applied in clinical practice still suffer from various obstacles, such as inevitable side effects.Fortunately, the application of nanotechnology and the proposal of co-delivery systems make the combination therapy more effective. The occurrence, development, and metastasis of tumors are closely related to the cell cycle. The sensitivity of tumor cells to chemotherapeutic drugs can be improved with the cooperation of cell cycle regulators. In this review, the influence of the cell cycle on tumorigenesis and development is introduced briefly. The current strategies of combining chemotherapeutic drugs and cell cycle regulators through codelivery systems are discussed in detail. We also sketch the possibility of treating tumors mildly via artificially controlling the cell cycle and outline the challenges and perspectives about the improvement of co-delivery systems for cancer therapy.
联合化疗是临床上用于克服肿瘤多药耐药性、提高肿瘤治疗效果的常用策略.然而在临床上,传统的联合用药仍存在诸多缺陷,如不可避免的副作用.纳米技术的应用和多药共同递送体系的提出使联合治疗的治疗效果得以显著提升.肿瘤的发生、发展和转移与细胞周期密切相关.因此,在化疗过程中配合使用细胞周期调节剂可以增强肿瘤细胞对化疗药物的敏感性.本综述首先简要介绍了细胞周期对肿瘤发生和发展的影响,然后详细讨论了目前通过多药共同递送体系结合化疗药物和细胞周期调节剂的一系列策略.最后,我们总结概述了通过调控细胞周期进行肿瘤治疗的挑战和前景.
作者
Ying Sun
Hao Hu
Xiaodong Jing
Qingye Meng
Bing Yu
Hailin Cong
Youqing Shen
孙莹;胡浩;荆晓东;孟庆业;于冰;丛海林;申有青(Institute of Biomedical Materials and Engineering,College of Materials Science and Engineering,Qingdao University,Qingdao 266071,China;Laboratory for New Fiber Materials and Modern Textile,Growing Base for State Key Laboratory,College of Chemistry and Chemical Engineering,Qingdao University,Qingdao 266071,China;Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027,China)
基金
supported by the National Natural Science Foundation of China (51703105,21675091,and 21874078)
Taishan Young Scholar Program of Shandong Province (tsqn20161027)
the Natural Science Foundation of Shandong Province (ZR2017BEM012)
the Major Science and Technology Innovation Project of Shandong Province (2018CXGC1407)
the Key Research and Development Project of Shandong Province (2016GGX102028,2016GGX102039,and 2017GGX20111)
China Postdoctoral Science Foundation (2018M630752)
the Postdoctoral Scientific Research Foundation of Qingdao
the First Class Discipline Project of Shandong Province (22074072)。
作者简介
contributed equally:Ying Sun received her BA degree in polymer material and engineering from Qingdao Uni-jp HI versity in 2019.She is pursuing her MSc degree in materials science in Prof.Cong’s laboratory.Her research focuses on the combination of cell cycle regulation and chemotherapy;contributed equally:Hao Hu received his PhD degree from Beijing University of Chemical Technology in 2016 with Prof.Fujian Xu.In 2016,he joined the College of Materials Science and Engineering at Qingdao University as a Lecturer.His research focuses on developing smart gene/drug delivery systems for cancer therapy;Corresponding author:Hailin Cong,received his PhD degree from Peking University in 2004 with Prof.Weixiao Cao.After completing a Postdoctoral Fellowship at the University of California,Davis,he joined Qingdao University in 2009 as a Distinguished Professor and Distinguished Young Scientist of Shandong Province.His current research interests lie in the synthesis and application of advanced micro-nano materials.He received The Natural Science Award from the Ministry of Education of China(2007).He has served as Member of Editorial Board of Nanoscience 8c Nanotechnology since 2008,Vice Chair of Editorial Committee of China International Nanoscience and Technology Symposium since 2009,and Member of Editorial Board of Integrated Ferroelectrics since 2012.
