摘要
目的探讨脐血炎性标志物在足月新生儿感染性疾病中的应用价值。方法选取2018年12月~2019年9月在陆军军医大学大坪医院出生并在产后24h内因感染住院的足月新生儿为病例组(41例),并选取同期在笔者医院出生的健康足月新生儿为对照组(46例)。收集纳入对象的病历资料及送检脐血炎性标志物(TNF-α、IL-1β、IL-2R、IL-6、IL-8及IL-10),分别比较两组宫内感染高危因素及炎性标志物水平,并绘制受试者工作曲线(ROC)及计算曲线下面积(AUC)。结果病例组中,宫内感染高危因素的占比较对照组显著升高(P<0.05)。与健康对照组比较,病例组中TNF-α、IL-2R、IL-6、IL-8及IL-10水平明显升高(P<0.05),而两组IL-1β比较,差异无统计学意义(P>0.05)。各炎性标志物TNF-α、IL-1β、IL-2R、IL-6、IL-8及IL-10的AUC分别为0.834、0.711、0.811、0.924、0.751及0.883。结论脐血炎性标志物TNF-α、IL-2R、IL-6、IL-8及IL-10有望成为新生儿感染性疾病的早期预警标志物。
Objective To explore the application value of umbilical cord blood inflammatory markers in infectious diseases of full-term neonates.Methods Full-term neonates who were born in Daping Hospital from December 2018 to September 2019 hospitalized due to infection within 24 hours after birth were enrolled in the case group(41 cases).Healthy full-term neonates during the same period in Daping Hospital were enrolled in the control group(46 cases).Medical records of all neonates were collected,and all samples of umbilical cord blood were tested to examine tumor necrosis factor alpha(TNF-α),interleukin-1beta(IL-1β),interleukin-2 receptor(IL-2R),IL-6,IL-8 and IL-10.High risk factors of intrauterine infection and the levels of inflammatory markers were compared between the two groups.Receiver operating characteristic(ROC)and area under the curve(AUC)were used to assess their values.Results Compared with control group,the proportion of high risk factors of intrauterine infection in case group is significantly higher(P<0.05).The levels of TNF-α,IL-2R,IL-6,IL-8,and IL-10 were significantly higher in case group than that in control group(P<0.05),but IL-1βshowed no significant difference between the two groups(P>0.05).The AUC of each inflammatory TNF-α,IL-1β,IL-2R,IL-6,IL-8,IL-10 marker showed below:0.834,0.711,0.811,0.924,0.751 and 0.883.Conclusion Inflammatory markers TNF-α,IL-2R,IL-6,IL-8,and IL-10 in umbilical cord blood are expected to be early warning markers of neonatal infectious diseases.
作者
刘慧
汪丽
Liu Hui;Wang Li(Department of Pediatrics,Daping Hospital,Army Medical University,Chongqing 400042,China)
出处
《医学研究杂志》
2021年第6期114-117,9,共5页
Journal of Medical Research
基金
重庆市技术创新与应用示范项目(cstc2018jscx-msybX0054)。
关键词
脐血炎性标志物
足月新生儿
感染性疾病
Umbilical cord blood inflammatory markers
Full-term neonates
Infectious diseases
作者简介
通讯作者:汪丽,电子信箱:liwang8771@126.com。
