摘要
目的探讨血清透明质酸(HA)、Ⅳ型胶原蛋白(ColⅣ)、层黏连蛋白(LN)和Ⅲ型前胶原N端肽(PⅢNP-P)在结缔组织病-间质性肺病(CTD-ILD)中的变化及意义。方法选取经临床确诊的结缔组织病患者157例,其中经肺部高分辨率CT(HRCT)确诊合并ILD的患者(CTD-ILD组)87例,未合并ILD患者(CTD-非ILD组)70例,收集2组患者的临床资料,并完善肺功能、血气分析、肺部HRCT、红细胞沉降率(ESR)、C-反应蛋白(CRP)、HA、ColⅣ、LN、PⅢNP-P等指标,分析HA、ColⅣ、LN和PⅢNP-P在CTD-ILD病情评估中的临床意义。结果CTD-ILD组患者血清HA、ColⅣ水平较CTD-非ILD组患者明显升高(P<0.05),2组患者ESR、CRP、PⅢNP-P和LN水平比较差异无统计学意义。CTD-ILD组血清HA水平与ESR、CRP、肺泡炎症评分和临床-影像-生理评分呈正相关(r_(s)分别为0.230、0.254、0.497和0.267,P<0.05),与动脉血氧分压[p(O2)]呈负相关(r_(s)=-0.318,P<0.01);CTD-ILD组血清ColⅣ与肺泡炎症评分呈正相关(r_(s)=0.212,P<0.05),与p(O2)呈负相关(r_(s)=-0.327,P<0.01)。结论血清HA、ColⅣ水平与CTD-ILD肺部炎症程度密切相关,对CTD-ILD有一定的预测价值,HA能作为反映CTD-ILD病情活动度的指标。
Objective Toexplore the significance of the serum changes of hyaluronic acid(HA),Ⅳtypecollagen,(ColⅣ),laminin(LN)and typeⅢbefore pre-collagen n-terminal peptide(PⅢNP-P)in connective tissue diseases-interstitial lung disease(CTD-ILD).Methods A total of 157 patients diagnosed as connective tissue disease were selected,including 87 patients with the lung high-resolution CT(HRCT)diagnosed with ILD(CTD-ILD group)and 70 patients without combined ILD(CTD-non-ILD group).The clinical data and serum test results were collected in 2 groups of patients.The pulmonary function test,blood gas analysis and lung HRCT,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),HA,ColⅣ,LN,PⅢNP-P and other indicators were also collected.The clinical significance of HA,ColⅣ,LN and PⅢNP-P in CTD-ILD was analyzed.Results The serum levels of HA and ColⅣwere significantly increased in CTD-ILD group compared with those of the CTD-non ILD group(P<0.05).There were no significant differences in serum ESR,CRP,PⅢNP-P and LN between the 2 groups of patients.The serum level of HA was positively correlated with ESR,CRP,alveolar inflammation score and clinical-radio-physiological score in CTD-ILD group(r_(s)=0.230,0.254,0.497 and 0.267,P<0.05),and negatively correlated with arterial oxygen partial pressure[p(O2)](r_(s)=-0.318,P<0.01).The serum level of ColⅣwas positively correlated with alveolar inflammation score in CTD-ILD group(r_(s)=0.212,P<0.05),and negatively correlated with p(O2)(r_(s)=-0.327,P<0.01).Conclusion The serum levels of HA and ColⅣare closely related to the degree of lung inflammation of CTD-ILD,suggesting its predictive value for CTD-ILD.HA is closely associated with the condition of CTD-ILD activity,which can be used as an indicator to reflect the disease activity of CTD-ILD.
作者
刘晓敏
孙慧莹
王永福
鲁芙爱
LIU Xiao-min;SUN Hui-ying;WANG Yong-fu;LU Fu-ai(Baotou Medical College of Inner Mongolia University of Science and Technology,Baotou 014010,China;Department of Rheumatology,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology)
出处
《天津医药》
CAS
北大核心
2021年第6期617-621,共5页
Tianjin Medical Journal
关键词
结缔组织疾病
肺疾病
间质性
透明质酸
胶原Ⅳ型
层黏连蛋白
细胞外基质
Ⅲ型前胶原N端肽
临床-影像-生理评分
connective tissue diseases
lung diseases,interstitial
hyaluronic acid
collagen typeⅣ
laminin
extracellular matrix
collagen typeⅢbefore n-terminal peptide
clinical radiographic physiologic score
作者简介
刘晓敏(1995),女,硕士在读,主要从事结缔组织病相关间质性肺病的诊治研究。E-mail:1282734827@qq.com;通信作者:鲁芙爱,E-mail:lufuai123456@126.com。
