摘要
银屑病的发病病因仍有待探究。目前,临床上尚未发现可根除该病的药物。中西医药物医治银屑病的措施较多,但仅对轻度患者有较佳疗效,对中、重度患者疗效不佳且长期用药存在诸多问题。随着科研人员对银屑病发病机制的认识和研究,大量的抗体药物开始兴起,其在缓解和治疗中、重度银屑病方面效果较佳,显示出很大的优势。现对银屑病目前的分类、发病因素及抗体药物治疗银屑病的研究进展进行了归纳,以期对银屑病的研究和治疗有所助益。
The causes of psoriasis have yet to been fully understood.To date there still exists no curable agents for the disease in clinic.A variety of combinations of traditional Chinese and western medicine have shown effectiveness in mild patients but been unsatisfactory,and long-term application may cause severe side effects in the treatment of moderate and severe patients.With better understanding of the pathogenesis of psoriasis in recent years,antibody therapeutics have begun to emerge and showed advantages in alleviating symptoms and even curing moderate and severe psoriasis.In this review,we intend to summarize the current classification,pathogenesis factors and the progress in the development of antibodys therapiesy for psoriasis,which may be helpful in facilitating future research and drug development in the field of psoriasis.
作者
李红霞
孙同毅
王春河
LI Hongxia;SUN Tongyi;WANG Chunhe(Shandong Key Laboratory of Proteins and Peptides Pharmaceutical Engineering,School of Life Science and Technology,Weifang Medical University,Weifang,Shandong,261053 P.R.China;Shanghai Institute of Materia Medica,Chinese Academy Sciences,Shanghai,201203 P.R.China)
出处
《华西药学杂志》
CAS
CSCD
2021年第3期325-330,共6页
West China Journal of Pharmaceutical Sciences
基金
中国科技部“重大新药创制”科技重大专项(2019ZX09732002)
中科院重大科技先导专项(XDA12020223
XDA12020330)
国家自然科学基金资助项目(批准号:81872785
81673347)
山东省高等学校青创科技支持计划(2019KJM003)。
作者简介
李红霞(1992-),女,宁夏回族自治区隆德,正攻读微生物学专业的硕士学位。Email:18369608751@163.com;通信作者:王春河,Email:wangc@simm.ac.cn。
