摘要
目的关于脊索瘤PET/CT相关研究鲜有报道,本研究探索颈椎原发性脊索瘤的18F-FDG PET/CT征象。资料与方法回顾性分析11例经病理证实的颈椎原发性脊索瘤的PET/CT及临床资料,总结病变CT表现及FDG代谢特征,测量病变最大标准化摄取值(SUVmax)及最大径线,分析病变代谢与形态特点的关系。结果11例病变均为单发,溶骨性破坏,其中位于C2椎体6例,C1、C1~2、C2~4、C2~5、C3~4各1例。病变平均SUVmax为5.16±0.32,平均长径(3.63±0.32)cm,两者无显著相关性(r=-0.151,P>0.05)。本组患者病变FDG代谢均增高。其中代谢均匀1例,呈均匀性等密度;代谢不均匀10例中,高代谢灶局限于骨破坏内4例,位于骨破坏区及椎旁肿块6例,其中密度不均匀5例、均匀1例。7例椎管内病灶代谢增高6例,等代谢1例。1例放疗后复查PET/CT,病变缩小、代谢减低。结论颈椎,尤其C2椎体发生的溶骨性破坏病变,伴邻近骨质、椎旁及椎管内侵犯,FDG代谢不均匀增高可作为诊断脊索瘤的重要征象。
Purpose There were few studies on primary chordoma in the cervical spine via PET/CT.This study aims to explore the 18F-FDG PET/CT patterns of primary chordoma in the cervical spine.Materials and Methods A total of 11 patients pathologically confirmed primary chordoma in the cervical spine were enrolled,and PET/CT and clinical data were retrospectively collected.The CT and FDG metabolic features of the lesions were summarized,the maximum standardized uptake value(SUVmax)and the maximum diameter were measured.The relationship between metabolic patterns and morphological characteristics were further calculated.Results All 11 cases showed solitary lesions with osteolytic destruction,including 6 cases located in C2 and 1 case in C1,C1-2,C2-4,C2-5,and C3-4,respectively.The mean SUVmax of all lesions were 5.16±0.32,with the average maximal diameter of(3.63±0.32)cm,and there was no significant correlation between SUVmax and maximal diameter(r=-0.151,P>0.05).Increased FDG uptakes were showed in all lesions,including 1 case with homogeneous uptake(isodensity)and 10 cases with heterogeneous uptake(hyperdensity).Among the high metabolic lesions,4 cases were showed with bone destruction,and 6 cases(including 5 heterogeneous density lesions and 1 homogeneous density lesion)were located in bone destruction area and paravertebral mass.Seven lesions were found in the spinal canal,including 6 lesions with hypermetabolism and 1 lesion with isometabolism.One patient underwent PET/CT after radiotherapy,with reduced size and decreased metabolism.Conclusion Chordomas with bone destruction locating in C2,involving the adjacent bone and the para-vertebral region,could be considered as one of the differential diagnoses.The heterogeneously increased FDG uptake could also be used as an important evidence for diagnosis of chordoma.
作者
宋乐
陈志波
张卫方
SONG Le;CHEN Zhibo;ZHANG Weifang(Department of Nuclear Medicine,Peking University Third Hospital,Beijing 100191,China;不详)
出处
《中国医学影像学杂志》
CSCD
北大核心
2021年第5期479-483,共5页
Chinese Journal of Medical Imaging
作者简介
通信作者:张卫方.tsy1997@126.com。
