摘要
目的分析老年科住院患者病原菌分布及其耐药性,为老年人合理使用抗菌药物提供依据。方法收集2019年1月至12月老年科患者痰液、尿液、血液等标本,进行病原菌分布及耐药性分析。结果共培养得到菌株624株,革兰阴性菌459株(73.6%);革兰阳性菌145株(23.2%);真菌20株(3.2%)。革兰阴性菌以大肠埃希菌(17.8%)、肺炎克雷伯菌(16.3%)和铜绿假单胞菌(10.7%)为主;革兰阳性菌以金黄色葡萄球菌(11.1%)和屎肠球菌(4.3%)为主;真菌以白色念珠菌(2.1%)为主。排名前五的革兰阴性菌对头孢咪唑的耐药率均>90%,对氨苄西林、头孢曲松、头孢他啶的耐药率均>50%,均对阿米卡星敏感;金黄色葡萄球菌对青霉素G的耐药率为100%,对苯唑西林、环丙沙星、左氧氟沙星耐药率均>80%,对利福平、万古霉素等均敏感。结论老年人常见病原菌感染仍以革兰阴性菌为主,对大部分抗菌药物均具有一定的耐药性,临床应定期进行耐药性分析,指导老年人抗菌药物的使用。
Objective To analyze the distribution and drug resitance of pathogenic bacteria in the geriatric inpatients of the Second People's Hospital of Lishui,and provide basis for the rational use of antibacterial drugs by the elderly.Methods The sputum,urine,blood and other specimens of geriatric patients were collected from January to December 2019 for pathogen distribution and drug resistance analysis.Results A total of 624 pathogens were cultured,including 459 gram-negative pathogens(73.6%),145 gram-positive pathogens(23.2%),and 20 fungi(3.2%).The mainly three gram-negative pathogens were Escherichia coli(17.8%),Klebsiella pneumoniae(16.3%)and Pseudomonas aeruginosa(10.7%).The mainly two gram-positive pathogens were Staphylococcus aureus(11.1%)and Enterococcus faecium(4.3%)。Candida albicans,as the mainly fuingus,accounted for only 2.1%.The top five gram-negative pathogens had a resistance rate of more than 90%to cefmnidazole,and more than 50%of the resistance rates to ampicilin,ceftriaxone.and ceftazidime,whereas susceptible to amikacin.The resistance rate of Staphylococcus aureus to penicllin G was 100%,and the drug resistance rate of oxacillin,ciprofloxacin,and levofloxacin was over 80%,and still sensitive to rifampicin and vancomycin.Conclusion The common pathogen infections in the elderly are still mainly Gram-negative pathogens,which have certain resistance to most antibacterial drugs.Clinical resistance analysis should be carried out regularly to guide the use of antibacterial drugs for the elderly.
出处
《浙江临床医学》
2021年第5期695-696,699,共3页
Zhejiang Clinical Medical Journal
基金
浙江省医药卫生科技计划项目(2019337835)。
关键词
老年科
老年人
病原菌
耐药性
Geriatrics
Elderly
Pathogens
Drug resistance
作者简介
通信作者:赵龙友。
