摘要
目的探讨术前白介素6(IL-6)水平对卵巢癌术后化疗后总生存率的影响。方法选取2012年3月30日~2016年6月30日在常州市妇幼保健院接受手术治疗的150例卵巢癌患者,检测术前及手术后第3天IL-6水平,对患者进行随访,随访截止日期为2019年6月,随访终点为死亡。分析IL-6水平与临床病理因素的相关性,使用Kaplan-Meier法分析IL-6与生存率相关性,使用Cox多因素回归模型分析生存时间的独立影响因素。结果失访16例,共随访134例,随访成功率89.3%,中位随访时间为46个月,共死亡42例。3年生存率为85.8%,5年生存率为70.1%。手术后IL-6水平低于术前(P<0.05)。ROC曲线结果显示,术前IL-6对卵巢癌生存率具有预测价值(P<0.05),截断值为147 ng/L。术前IL-6升高组(>147 ng/L)50例,术前IL-6降低组(≤147 ng/L)84例。术前IL-6升高组淋巴结转移率、Ⅲ期比例高于术前IL-6降低组(P<0.05)。Kaplan-Meier加Log-rank检验显示,术前IL-6水平升高患者总生存期短于IL-6水平降低患者(P<0.05),术后IL-6水平与总生存期无相关性(P>0.05)。Cox回归分析显示,术前IL-6水平、FIGO分期、淋巴结转移、分化程度是总生存期的独立预后因素(P<0.05)。结论术前IL-6水平与卵巢癌肿瘤分期和淋巴结转移相关,对预后具有一定预测价值。
Objective To investigate the effect of preoperative IL-6 level on the overall survival rate of postoperative chemotherapy for ovarian cancer.Methods A total of 150 patients with ovarian cancer who underwent surgery in Changzhou Maternal and Child Health Hospital from March 30,2012 to June 30,2016 were enrolled.The IL-6 level was measured before and 3 days after surgery.The patients were followed up and the follow-up deadline date was June 2019,the end point of follow-up was death.The correlation between IL-6 level and clinicopathological factors was analyzed.The correlation between IL-6 and survival rate was analyzed by Kaplan-Meier method.The independent influence factors of survival time were analyzed by Cox multivariate regression model.Results Sixteen patients were lost to follow-up.A total of 134 patients were followed up.The success rate of follow-up was 89.3%.The median follow-up time was 46 months.A total of 42 patients died.The 3-year survival rate was 85.8%,and the 5-year survival rate was 70.1%.The level of IL-6 after surgery was lower than that before surgery(P<0.05).The results of ROC curve showed that preoperative IL-6 had predictive value for ovarian cancer survival rate(P<0.05)and preoperative IL-6 cutoff value was 147 ng/L.There were 50 patients with preoperative IL-6 elevation(>147 ng/L)and 84 patients with preoperative IL-6 reduction(≤147 ng/L).The rate of lymph node metastasis and phaseⅢin the elevated IL-6 group was higher than that in the IL-6 group(P<0.05).Kaplan-Meier and Log-rank test showed that patients with elevated IL-6 levels had shorter overall survival than patients with decreased IL-6 levels(P<0.05),and postoperative IL-6 levels were not associated with overall survival(P>0.05).Cox regression analysis showed that preoperative IL-6 level,FIGO stage,lymph node metastasis,and degree of differentiation were independent prognostic factors for overall survival(P<0.05).Conclusion Preoperative IL-6 level is associated with ovarian cancer tumor stage and lymph node metastasis,and has a certain predictive value for prognosis.
作者
徐娟
陆抗美
谭青青
XU Juan;LU Kang-mei;TAN Qing-qing(Department of Gynecology Oncology,Changzhou 213000,China)
出处
《哈尔滨医科大学学报》
CAS
2021年第1期49-53,共5页
Journal of Harbin Medical University
基金
江苏省自然科学基金资助项目(BK20151573)。
关键词
卵巢癌
生存率
IL-6
ovarian cancer
survival rate
IL-6
作者简介
通讯作者:徐娟(1980-),女,副主任医师,硕士,E-mail:xl377583056@163.com。
