摘要
目的:探讨阻塞性睡眠呼吸暂停(OSA)合并原发性醛固酮增多症(PA)患者血清白介素-1β(IL-1β)的水平及其影响因素。方法:选取2013年4-12月行整夜多导睡眠呼吸监测且经过PA筛查及诊断流程的中年男性患者133例,将患者分为OSA合并PA组、单纯OSA组和原发性高血压(EH)三组。比较三组患者IL-1β水平,并进行影响因素分析。结果:133例患者中,OSA合并PA 13例,单纯OSA 93例,EH 27例。OSA合并PA组IL-1β水平高于EH组,差异有统计学意义(P<0.05);OSA合并PA组与OSA组以及OSA组与EH组IL-1β水平比较,差异无统计学意义(P>0.05)。Spearman相关分析显示,IL-1β水平与最低血氧饱和度(LSaO_(2))呈负相关(r=-0.201,P<0.05);与血浆醛固酮浓度(PAC)呈正相关(r=0.202,P<0.05)。结论:OSA及PA病情和血清IL-1β水平存在一定相关性,对血清IL-1β的检测有利于了解OSA及PA的发生和发展机制。
Objective:To investigate the level of serum interleukin-1β(IL-1β)in patients with obstructive sleep apnea(OSA)complicated with primary aldosteronism(PA)and its influencing factors.Methods:During April to December 2013,133 middle-aged male patients who underwent overnight polysomnography(PSG)and underwent PA screening and diagnostic procedures were enrolled,and divided into OSA combined PA group,OSA group and essential hypertension(EH)group.The IL-1βlevel of the three groups was compared and the influencing factors were analyzed.Results:Among the 133 patients,13 cases had OSA combined with PA,93 cases had OSA alone,and 27 cases had EH.OSA combined PA group had a higher IL-1βlevel than the EH group,the difference was statistically significant(P<0.05).IL-1βlevel between OSA combined PA group and OSA group and between OSA group and EH group was compared,the difference was not statistically significant(P>0.05).Spearman correlation analysis showed that,there was a negative correlation between IL-1βlevel and LSaO2(r=-0.201,P<0.05).IL-1βlevel had a positive correlation with plasma aldosterone concentration(PAC)(r=0.202,P<0.05).Conclusion:Serum IL-1βlevel was higher in OSA combined PA group than EH group,and correlated with LSAO_(2)and PAC.The detection of serum IL-1βis helpful to understand the pathogenesis of OSA and PA.
作者
阿依妮格尔·阿布力米提
骆秦
朱晴
李南方
Ayinigeer Abulimiti;Luo Qin;Zhu Qing;Li Nanfang(Hypertension Center of People's Hospital Of Xinjiang Uygur Autonomous Region,Hypertension Research Institute of Xinjiang,NHC Key Laboratory of Hypertension Clinical Research,Urumqi,Xinjiang 830001)
出处
《中国社区医师》
2021年第15期118-119,共2页
Chinese Community Doctors
基金
国家卫生健康委高血压诊疗研究重点实验室、中国医学科学院中央级公益性科研院所基本科研业务费专项资金资助(2019PT330003)。
作者简介
通信作者:李南方。
