摘要
Type 1 diabetes(T1D)is an autoimmune disease that resulted from the severe destruction of the insulin-producingβcells in the pancreases of individuals with a genetic predisposition.Genome-wide studies have identified HLA and other risk genes associated with T1D susceptibility in humans.However,evidence obtained from the incomplete concordance of diabetes incidence among monozygotic twins suggests that environmental factors also play critical roles in T1D pathogenesis.Epigenetics is a rapidly growing field that serves as a bridge to link T1D risk genes and environmental exposures,thereby modulating the expression of critical genes relevant to T1D development beyond the changes of DNA sequences.Indeed,there is compelling evidence that epigenetic changes induced by environmental insults are implicated in T1D pathogenesis.Herein,we sought to summarize the recent progress in terms of epigenetic mechanisms in T1D initiation and progression,and discuss their potential as biomarkers and therapeutic targets in the T1D setting.
基金
supported by grants from the Ministry of Science and Technology(Nos.2016YFC1305002 and 2017YFC1309603)
the National Natural Science Foundation of China(Nos.81530024,91749207,81920108009,81770823,and 81670729)
the NHC Drug Discovery Program(No.2017ZX09304022-07)
the Department of Science and Technology of Hubei State(No.2017ACA096)
the Integrated Innovative Team for Major Human Disease Programs of Tongji Medical College,Huazhong University of Science and Technology
the Innovative Funding for Translational Research from Tongji Hospital.
作者简介
Jing Zhang,contributed equally to this work;Long-Min Chen,contributed equally to this work;Correspondence to:Drs.Cong-Yi Wang,The Center for Biomedical Research,Tongji Hospital Research Building,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 431000,China E-Mail:wangcy@tjh.tjmu.edu.cn;Correspondence to:Drs.Fei Xiong,The Center for Biomedical Research,Tongji Hospital Research Building,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 431000,China E-Mail:feixiong@tjh.tjmu.edu.cn。
