摘要
目的分析母乳库建立对早产儿生命质量的影响。方法采用前瞻性分析的研究方法,选取2014年1月至2018年12月期间于秦皇岛市妇幼保健院住院且出生体重<1 500g的516例早产儿为研究对象,将其采用随机数字表法分为A、B、C三组,每组均为172例。A组给予配方奶喂养,B组为亲母喂养,C组为母乳库捐奶喂养,比较三组早产儿的喂养及住院情况、喂养4w时的发育情况及生化指标、喂养过程中的并发症情况。结果与A组相比,B组和C组早产儿的平均肠内营养时间、建立喂养耐受时间、平均住院时间均缩短,出院时体质量均增高,而B组和C组比较无明显差异(F值分别为5.279、13.621、6.347、4.017,均P<0.05);与A组相比,B组和C组早产儿喂养4w时的身长、头围、上臂围、体质量增长率均升高,而B组和C组比较无明显差异(F值分别为4.976、6.013、13.279、4.379,均P<0.05);与A组相比,B组和C组早产儿喂养4w时的血清尿素氮(BUN)、血肌酐(SCr)、直接胆红素(DBIL)水平均升高,而B组和C组比较无明显差异(F值分别为5.383、4.976、5.571,均P<0.05);与A组相比,B组和C组早产儿的坏死性小肠结肠炎(NEC)、消化不良、脓毒症、支气管肺发育不良(BPD)发生率均降低,而B组和C组比较无明显差异(χ^(2)值分别为4.523、13.816、6.128、4.679,均P<0.05)。结论母乳库捐奶喂养与亲母喂养临床效果相近,能够改善早产儿营养状况,促进生长和体质量恢复,缩短住院时间,且并发症发生率低于配方奶喂养,安全性较佳。
Objective To investigate effect of establishment of breast milk bank on quality of life(QOL) of premature infants.Methods 516 premature infants with birth weight < 1 500 g who admitted to Qinhuangdao Municipal Maternity and Child Health Hospital from January 2014 to December 2018 were selected as research subjects in prospective analysis method.They were divided into groups A,B and C in random number table method(172 cases in each group).The premature infants in Group A were fed with formula milk powder, the premature infants in Group B were fed with mother’ breast milk, and those infants in Group C were fed with donor’s breast milk from breast milk bank.The feeding condition indexes and hospitalization of the premature infants, growth and development and biochemical indexes after feeding for 4 weeks and complications during the feeding were compared among the three groups.Results Compared with Group A,the average intraenteral nutrition time, feeding tolerance time and average hospital stay of the premature infants in Group B and Group C were shortened, and the body weight at discharge was increased, but there were no significant differences between Group B and Group C(F=5.279,13.621,6.347 and 4.017 respectively, all P<0.05).Compared with Group A,the increase velocities in body length, head circumference, upper arm circumference and body weight of the premature infants in Group B and Group C were higher after feeding for 4 weeks, but there were no significant differences between Group B and Group C(F=4.976,6.013,13.279 and 4.379 respectively, all P<0.05).Compared with Group A,blood urea nitrogen(BUN),serum creatinine(SCr) and direct bilirubin(DBIL) levels of the premature infants in Group B and Group C were increased after feeding for 4 weeks, but there were no significant differences between Group B and Group C(F=5.383,4.976 and 5.571 respectively, all P<0.05).Compared with Group A,the incidence rates of necrotizing enterocolitis(NEC),dyspepsia, sepsis and bronchopulmonary dysplasia(BPD) in the premature infants in Group B and Group C were decreased, but there were no significant differences between Group B and Group C(χ^(2)=4.523,13.816,6.128 and 4.679 respectively, all P<0.05).Conclusion The clinical effect of donor’s breast milk feeding is similar to that of maternal breast milk feeding, which can improve nutritional status of the premature infants, promote growth and body weight recovery, shorten length of hospital stay, and incidence of complications is lower than formula milk powder feeding, and the safety is better.
作者
陈宁
才海燕
高彩云
苗晓霞
刘芳
朱洪斌
杜秋影
CHEN Ning;CAI Haiyan;GAO Caiyun;MIAO Xiaoxia;LIU Fang;ZHU Hongbin;DU Qiuying(Department of Neonatology,Qinhuangdao Municipal Maternity and Child Health Hospital,Hebei Qinhuangdao 066000,China)
出处
《中国妇幼健康研究》
2021年第5期677-681,共5页
Chinese Journal of Woman and Child Health Research
基金
秦皇岛市科学技术研究与发展计划项目(201602A107)。
关键词
配方奶喂养
亲母喂养
母乳库捐奶喂养
早产儿
生长状况
formula milk powder feeding
maternal breast milk feeding
donor’s breast milk feeding
premature infant
growth
作者简介
陈宁(1985-),女,主治医师,主要从事早产儿管理、儿科内分泌研究;通讯作者:高彩云,主任医师。
