摘要
Objective:To evaluate the clinical efficacy of infusion of gemcitabine(GEM) and fluorouracil(5-FU)through the celiac artery and superior mesenteric artery in the treatment of pancreatic carcinoma(PC).Methods:We analyzed 20 patients diagnosed clinically or pathologically with PC,without metastases,who had an estimated survival duration of>3 months in our department from May 2009 to December 2014.Nine patients were treated directly without surgical resection of the tumor,while the other 11 patients were treated after surgery.In all patients,the femoral artery was punctured using the Seldinger technique,and a catheter was placed in the opening of the celiac artery or the superior mesenteric artery.We administered 500 mg/m2 GEM and 500 mg/m2 5-FU.Observational data included data on clinical efficacy and survival rates during the follow-up period of 3-72 months.Results:Twenty patients were treated 85 times with transcatheter arterial infusion chemotherapy(TAI).The survival rates were 80%,40%,35%,20%,10%,and 5% at 3,6,12,24,and 72 months,respectively.Conclusion: TAI chemotherapy with GEM and 5-FU may be a therapeutic option for the treatment of PC.
基金
funded by Zhejiang Provincial Natural Science Foundation of China (Grant No. LZ18H180001)
National Natural Science Foundation of China (Grant No. 81971713 and 81,371,658)
National S&T Major Project of China (NO.2018ZX10301201)
Grant from Health Commission of Zhejiang Province (JBZX-202004)
Research Unit of Collaborative Diagnosis and Treatment For Hepatobiliary and Pancreatic Cancer,Chinese Academy of Medical Sciences (2019RU019)
The Key Research Development Program of Zhejiang province (Grant No.2018C03018)
Key Science and Technology Program of Zhejiang province (No.WKJ-ZJ-1923)
National Key R&D Program of China(No.2017YFC0114102)。
作者简介
Corresponding author:Junhui Sun,Hepatobiliary and Pancreatic Interventional Treatment Center,Division of Hepatobiliary and Pancreatic Surgery,The First Affiliated Hospital,Zhejiang University School of Medicine,Zhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases,#79 Qingchun Road,310003,Zhejiang Province,China.E-mail address:1307005@zju.edu.cn。
