摘要
目的观察四君子汤合生脉散加减对反复呼吸道感染(RRTI)缓解期气阴两虚证患儿血清免疫球蛋白、微量元素水平的影响。方法将112例RRTI缓解期气阴两虚证患儿按照随机数字表法分为2组。对照组56例予匹多莫德颗粒口服治疗,治疗组56例在对照组治疗基础上予四君子汤合生脉散加减治疗。2组均连续治疗4周。比较2组治疗前后中医症状评分、血清免疫球蛋白[免疫球蛋白G(IgG)、IgA及IgM]、血清微量元素[铁(Fe)、锌(Zn)]水平、1年内呼吸道感染发作次数及每次发作持续时间,统计疗效及不良反应发生情况。结果治疗组总有效率87.5%(49/56),对照组总有效率71.4%(40/56),治疗组疗效优于对照组(P<0.05)。治疗后2组各中医症状评分均较本组治疗前降低(P<0.05),且治疗后治疗组均低于对照组(P<0.05)。治疗后2组血清IgG、IgA、IgM水平均较本组治疗前升高(P<0.05),且治疗后治疗组均高于对照组(P<0.05)。治疗后2组血清Fe、Zn水平均较本组治疗前升高(P<0.05),且治疗后治疗组均高于对照组(P<0.05)。治疗后2组呼吸道感染发作次数均较本组治疗前降低(P<0.05),每次发作持续时间均缩短(P<0.05),且治疗后治疗组呼吸道感染发作次数均低于对照组(P<0.05),每次发作持续时间均短于对照组(P<0.05)。结论四君子汤合生脉散加减能够提高RRTI缓解期气阴两虚证患儿血清免疫球蛋白水平,调节血清微量元素水平,减少呼吸道感染发作次数,有助于改善临床预后。
Objective To observe the effect of Sijunzi Decoction combined with Shengmai Powder addition and subtraction therapy on levels of serum immunoglobulins and trace elements of children with recurrent respiratory tract infection(RRTI)concurrent with Qi and Yin deficiency syndrome.Methods A total of 112 children with RRTI concurrent with Qi and Yin deficiency syndrome were randomly divided into two groups,56 cases per group.The control group were treated with pidotimod granules orally,the treatment group were additionally treated with Sijunzi Decoction combined with Shengmai Powder addition and subtraction on the basis of the control group.The course of treatment was 4 weeks.The symptom scores,serum immunoglobulin levels[immunoglobulin G(IgG),IgA and IgM]and the serum trace element level(Fe,Zn),the number of episodes of respiratory tract infection per year and the duration of each infection were compared between the two groups before and after treatment.The curative effect and the occurrence of adverse reactions were counted.Results The total effective rate in the treatment group was better than that in the control group[87.5%(49/56)vs 71.4%(40/56),(P<0.05),respectively].After treatment,the symptom scores in the two groups were lower than those before treatment(P<0.05),which was lower in the treatment group than the control group(P<0.05);the levels of serum IgG,IgA,IgM in the two groups were higher than those before treatment(P<0.05),which in the treatment group were higher than the control group(P<0.05);the levels of serum Fe and Zn in the two groups were higher than those before treatment(P<0.05),which in the treatment group were higher than the control group(P<0.05);the number of episodes of respiratory tract infection in the two groups were lower than those before treatment(P<0.05),and the duration of each infection was shorter(P<0.05),which in the treatment group were lower and shorter than control group(P<0.05).Conclusion The Sijunzi Decoction combined with Shengmai Powder addition and subtraction therapy can improve the serum immunoglobulin level of children with RRTI concurrent with Qi and Yin deficiency syndrome,regulate the level of trace elements,reduce the frequency of respiratory tract infection,which can help to improve the clinical prognosis.
作者
高娇娇
曹燕玲
李文斌
卢艳辉
GAO Jiaojiao;CAO Yanling;LI Wenbin;LU Yanhui(Department of Pediatrics,The First Affiliated Hospital of Hebei North University,Hebei,Zhangjiakou 075000)
出处
《河北中医》
2021年第2期209-213,共5页
Hebei Journal of Traditional Chinese Medicine
基金
河北省2020年度医学科学研究课题计划(编号:20200530)。
关键词
四君子汤
生脉散
呼吸道感染
中医儿科疾病
中药疗法
Sijunzi Decoction
Shengmai Powder
Respiratory tract infection
Pediatric diseases of traditional Chinese medicine
Traditional Chinese medicine therapy
作者简介
高娇娇(1992-),女,医师,硕士。从事儿内科临床工作。
