摘要
目的分析T细胞非霍奇金淋巴瘤患者的临床病理因素及其与预后的相关性。方法回顾性分析T细胞非霍奇金淋巴瘤患者60例临床资料,整理入选者所有基础资料与病理资料,如年龄、性别、症状、肿瘤部位、病变直径、临床分期、乳酸脱氢酶(LDH)变化及治疗情况等。随访3年,记录生存状况,并分析病理表现与预后关系。结果T细胞非霍奇金淋巴瘤发病以男性、≥60岁人群居多,初期症状表现为消化系统症状,病变部位主要为结内,病变直径大部分<10 cm,LDH升高占比较少。随访3年,60例T细胞非霍奇金淋巴瘤患者生存率为26.67%(16/60)。单因素分析显示年龄≥60岁、B组症状、病变直径≥10 cm、临床分期Ⅲ~Ⅳ期、LDH升高与预后不良有关(P<0.05),性别、病变部位则与预后无明显关系(P>0.05);Logistic回归分析:年龄≥60岁、B组症状、病变直径≥10 cm、临床分期Ⅲ~Ⅳ期、LDH升高是影响T细胞非霍奇金淋巴瘤患者预后的独立危险因素(P<0.05且OR≥1)。结论T细胞非霍奇金淋巴瘤患者临床病理表现复杂,且预后较差,年龄、症状、肿瘤直径、分期、LDH水平均与预后相关,临床需予以高度重视。
Objective To analyze the clinicopathological factors of T cell non-Hodgkin's lymphoma and its correlation with prognosis.Methods The clinical data of 60 patients with T cell non-Hodgkin lymphoma were retrospectively analyzed,all basic and pathological data of the candidates,age,sex,symptoms,tumor site,lesion diameter,clinical stage,lactate dehydrogenase(LDH)changes and treatment were collected.Followed up for 3 years,and record survival,The pathological manifestations and their relationship with prognosis were analyzed.Results The majority of patients with T cell non-Hodgkin's lymphoma were men and≥aged 60,Initial symptoms are digestive symptoms,The lesion was mainly in the knot,Most of the lesions<10 cm,(b)LDH increases were relatively small;For 3 years,60 patients with T cell non-Hodgkin lymphoma had a survival rate of 26.67%(16/60);age≥60 years,B group symptoms,lesion diameter≥10 cm、clinical stage III-IV,increased LDH were associated with poor prognosis,difference was statistically significant(P<0.05);Sex,lesion location and prognosis were not significant,(b)The difference was not statistically significant(P>0.05);Logistic regression analysis:age≥60 years,B group symptoms,lesion diameter≥10 cm、clinical stage iii-iv,increased LDH were independent risk factors for prognosis in patients with non-hodgkin lymphoma of T cells(0.05 and OR≥1).Conclusion T cell non-Hodgkin's lymphoma has complicated clinicopathological findings and the prognosis is poor.Age,symptoms,tumor diameter,stage and LDH level are all related to the prognosis.
作者
邢伟
XING Wei(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)
出处
《实用癌症杂志》
2021年第5期853-855,共3页
The Practical Journal of Cancer
关键词
T细胞非霍奇金淋巴瘤
病理因素
预后
相关性
T cell non-Hodgkin's lymphoma
Pathological factors
Prognosis
Correlation
