摘要
目的探讨重症监护室患者伏立康唑血药浓度对药物疗效和不良反应的影响。方法收集2019年1月~2019年11月在重症监护室使用伏立康唑的患者资料,测定达稳态后伏立康唑的血药浓度。结果60例患者平均血药浓度(3.99±2.94)mg/L,34例血药浓度在正常范围内。不同性别、年龄的药物浓度差异无统计学意义(P>0.05)。33例使用伏立康唑治疗后有好转,平均血药浓度为(4.26±3.11)mg/L,未好转组平均血药浓度为(3.66±2.75)mg/L。60例患者的主要不良反应为肝功能异常,平均血药浓度为(3.75±3.10)mg/L。结论重症监护室患者伏立康唑血药浓度个体差异大,需密切监测血药浓度,指导合理用药。
Objective To explore the effect of voriconazole plasma concentration in Intensive Care Unit on the efficacy and adverse drug reaction.Methods We collected clinical data of patients who used voriconazole in Intensive Care Unit from January 2019 to November 2019,and monitored the plasma concentration of voriconazole after reaching steady state.Results Plasma concentration of 60 patients showed great variation,and the average plasma concentration was(3.99±2.94)mg/L.34 patients were the normal concentrations.There was no difference between different gender and age(P>0.05).33 patients completely or partial responded to the therapy,and the average plasma concentration was(4.26±3.11)mg/L.The average plasma concentration of the non-improved group was(3.66±2.75)mg/L.The liver function of 60 patients was damaged,and the average plasma concentration was(3.75±3.10)mg/L.Conclusion The plasma concentration of voriconazole in the intensive care unit varies greatly among individuals,and plasma concentration should be closely monitored to guide rational drug use.
作者
刘惠
高杏
LIU Hui;GAO Xing(Department of Pharmacy,West Hospital of Xuzhou Medical University Affiliated Hospital of Jiangsu Province(Fifth Coal Construction Company Workers Hospital),Xuzhou 221006,China)
出处
《中国处方药》
2021年第5期60-61,共2页
Journal of China Prescription Drug
基金
2017年度江苏省药学会奥赛康课题(A2017014)。
关键词
伏立康唑
血药浓度
疗效
不良反应
Voriconazole
Plasma concentration
Clinical efficacy
Adverse drug reaction
作者简介
通信作者:高杏,Email:panda864170@126.com。
