摘要
骨关节炎(OA)是以关节软骨退变、软骨下骨硬化为主要特征的关节退行性疾病。病理特点为关节软骨变性破坏、软骨下骨硬化或囊性变、关节边缘骨质增生、滑膜病变、关节囊挛缩、韧带松弛或挛缩、肌肉萎缩无力等。近年来研究发现软骨下骨硬化是OA的一个病因,软骨下骨硬化优于并加速软骨退变,进而加速OA的发生发展。抑制或延缓软骨下骨硬化对于OA的治疗具有重大的意义。本文针对以软骨下骨硬化为靶点的OA治疗研究进展进行综述,为后续基础研究及临床工作提供帮助。
Osteoarthritis(OA)is a joint degenerative disease characterized by articular cartilage degeneration and subchondral osteosclerosis.The pathological features were articular cartilage degeneration and destruction,subchondral osteosclerosis or cystic change,articular marginal hyperosteogeny,synovial lesions,articular capsule contracture,ligament relaxation or contracture,muscle atrophy and weakness,etc.In recent years,studies have found that subchondral osteosclerosis is a cause of OA,and subchondral osteosclerosis is superior to and accelerates the degeneration of cartilage,thus accelerating the development of OA.It is of great significance to inhibit or delay subchondral osteosclerosis in the treatment of OA.This article reviewed the research progress of OA treatment with subchondral bone sclerosis as the target,and provides help for follow-up basic research and clinical work.
作者
杨明义
苏亚妮
马尧
许珂
何昌军
黄王利
李庆达
任小宇
郝博
许鹏
Yang Mingyi;Su Yani;Ma Yao;Xu Ke;He Changjun;Huang Wangli;Li Qingda;Ren Xiaoyu;Hao Bo;Xu Peng(Yan ′an university, Yan′an 716000, China;Joint Reconstruction Department, Honghui Hospital, Xi′an Jiaotong University, Xi′an 710054, China)
出处
《中华关节外科杂志（电子版）》
CAS
CSCD
2021年第2期209-213,共5页
Chinese Journal of Joint Surgery(Electronic Edition)
基金
国家自然科学基金(81772410,81601877)
中国博士后科学基金(2020M673454)。
关键词
软骨
研究
骨关节炎
治疗学
Cartilage
Research
Osteoarthritis
Therapeutics
作者简介
通讯作者:许鹏,Email:sousou369@163.com。
