摘要
肠道菌群与人类健康和疾病密切相关。粪菌移植通过恢复肠道菌群稳态、调控肠道免疫应答等,可用于治疗多种疾病。近年来,随着相关基础和临床研究的开展,粪菌移植在血液系统疾病中的应用也有了很多的探索和突破。文章从粪菌移植在造血干细胞移植、免疫性血小板减少性紫癜、血液肿瘤免疫治疗、未来前景等方面,结合国内外最新研究进展进行阐述,为继续开展相关临床研究提供借鉴。
Intestinal microbiome plays a critical role in human health and many diseases. Fecal microbiota transplantation(FMT)has been proven to be a highly effective modality for many diseases,by restoring intestinal microflora homeostasis and regulating immune response. Recently,FMT in treating hematologic diseases has made great progress. This article reviews the application of FMT in immune thrombocytopenia,hematiopoietic cell transplantation,immunotherapy and its prospect,as well as the latest advances in this field,providing a reference for the further clinical study.
作者
吴德沛
赵晔
WU De-pei;ZHAO Ye(National Clinical Research Center for Hematologic Diseases,Jiangsu Institute of Hematology,The First Affiliated Hospital o f Soochow University,Suzhou 215000,China;Institute of Blood and Marrow Transplantation of Soochow University,Suzhou 215000,China)
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2021年第4期265-267,共3页
Chinese Journal of Practical Internal Medicine
基金
国际(地区)合作与交流项目(82020108003)
国家科技重大专项课题(2017ZX09304021)
国家重点研发计划(2019YFC0840604,2017YFA0104502)
江苏省重点研发计划(BE2019798)。
关键词
肠道菌群
粪菌移植
血液系统疾病
intestinal microbiome
fecal microbiota transplantation
hematologic diseases
作者简介
吴德沛,E-mail:drwudepei@163.rom。
