摘要
心血管疾病已成为威胁人类生命的主要疾病,其诱发的病理性心脏重构是导致心功能逐步恶化的关键因素。而补体C1q/肿瘤坏死因子相关蛋白(CTRPs)对心脏重构具有一定的调节作用,且适宜运动可有效促进相关CTRPs分泌,减少病理性心脏重构。但目前的研究仅将运动作为一种积极的干预方式,有关通过运动调控CTRPs变化进而改善心脏功能的研究较少。未来,可进一步发掘CTRPs在心脏重构中的作用及运动调控的分子机制,以为运动调控CTRPs的动物和人体研究提供理论依据,并为改善病理性心脏重构制订恰当的运动方案提供指导性建议。
Cardiovascular disease has become the main disease threatening human life,and the induced pathological cardiac remodeling is the key factor leading to the gradual deterioration of cardiac function.The complement C1q/tumor necrosis factor-related protein(CTRPs)can regulate cardiac remodeling to a certain extent,and suitable exercise can effectively promote the secretion of related CTRPs and reduce pathological cardiac remodeling.However,in the present study,exercise is only regarded as a positive intervention mode,and there are few studies on the exercising changing CTRPs and then improving cardiac function.The future research can further explore the role of CTRPs in cardiac remodeling and the molecular mechanism of motor regulation,and provide theoretical basis for animal and human research on exercising regulation of CTRPs,so as to provide guidance to formulate appropriate exercise prescription for the improvement of pathological cardiac remodeling.
作者
唐菊丽
柳华
杨翼
TANG Juli;LIU Hua;YANG Yi(Graduate School,Wuhan Sports University,Wuhan 430079,China;College of Health Science,Wuhan Sports University,Wuhan 430079,China;Fitness Monitoring and Chronic Disease Intervention Research Center,Wuhan Sports University,Wuhan 430079,China)
出处
《医学综述》
CAS
2021年第9期1679-1684,共6页
Medical Recapitulate
基金
国家自然科学基金(81970261,81700280)。
作者简介
通信作者:杨翼,Email:yangyi999999@yahoo.com。
