摘要
目的进行天麻提取物辅助降血脂的功能评价。方法大鼠随机分为正常组、模型组、辛伐他汀组(4 mg/kg)、天麻乙醇提取物高(1 g/kg)、低(0.2 g/kg)剂量组,正常组普通饮食,其余各组通过高脂饮食复制大鼠高脂血症模型,连续给药120 d。给药结束,测定大鼠的血脂(TG、TC、HDL-C、LDL-C)、肝功能(AST、ALT)并观察肝组织病理损伤情况。结果与正常组比较,模型组TC、LDL-C明显升高(P<0.05);与模型组比较,天麻提取物高剂量组能降低模型大鼠TC、LDL-C水平(P<0.05),降低血清及肝组织中AST及肝组织ALT水平(P<0.05)。天麻提取物低剂量组仅能降低大鼠血清中LDL-C及肝组织AST、ALT水平(P<0.05),天麻提取物给药后能减轻肝组织损伤。结论天麻提取物能降低血脂水平,减轻肝脏病变程度,说明天麻提取物具有辅助降血脂功能。
Objective To evaluate the function of extracts from Gastrodiae Rhizoma in reducing blood lipid.Methods Rats were randomly divided into normal group,model group,simvastatin group(4 mg/kg),Gastrodiae Rhizoma extracts high dose group(1 g/kg),low dose group(0.2 g/kg).The normal group was fed with normal diet,and the other groups were fed with high-fat diet,the treatment were lasted for 120 d.At the end of the treatment,lipid levels(TG,TC,HDL-C,LDL-C)and liver AST,ALT were measured,also liver histological changes were observed.Results Compared with the normal group,TC and LDL-C in the model group increased significantly(P<0.05).Compared with the model group,the high dose group of Gastrodiae Rhizoma extracts decreaseed the levels of TC and LDL-C(P<0.05).It was also reduced the levels of serum(AST),liver tissue AST and ALT(P<0.05).The low dose group of Gastrodiae Rhizoma extracts only decreaseed the LDL-C level in serum and the levels of AST,ALT in liver tissue(P<0.05).Both Gastrodiae Rhizoma extracts groups were able to improve liver tissue damage.Conclusion It is suggested that the Rhizoma Gastrodiae extracts could reduce the level of blood lipid and improve liver injury,have the function in reducing blood lipid.
作者
孙航
代蓉
宁珑
何芳雁
SUN Hang;DAI Rong;NING Long;HE Fangyan(School of Chinese materia medic,Yunnan University of Chinese Medicine,Kunming650500,China)
出处
《云南中医学院学报》
2020年第6期6-11,共6页
Journal of Yunnan University of Traditional Chinese Medicine
基金
国家自然科学基金项目(81660677)
云南省科技厅-云南中医学院中医联合重点项目[2018FF001(-007)、2017FF117(-004)]
云南省科技厅-云南中医学院中医联合青年项目[2018FF001(-074)]。
关键词
天麻
高脂血症模型大鼠
降血脂
Gastrodiae Rhizoma
hyperlipidemia model rats
reducing blood lipid
作者简介
第一作者:孙航(1997-),女,在读硕士研究生,研究方向:中药药理学;通信作者:何芳雁,E-mail:735137511@qq.com。
