摘要
女性阴道微生态具有特殊、庞杂、动态演变等特性。健康的阴道微生物群(VM)与各类免疫细胞及保护性蛋白共同构成了女性粘膜生殖道的先天防御系统。随着近年微生物多组学技术的普及,阴道微生态在人乳头瘤病毒(HPV)等各类妇科感染性疾病发生、发展过程中的重要性被不断揭示,但两者之间的关系仍未明确。本文将回顾阴道微生态与常见妇科感染性疾病之间的相关性研究,并重点对HPV感染的发展与进程中阴道微生态的变化、宫颈局部免疫与HPV清除转归的关系进行评述与总结,以期为临床工作者提供新的见解。
The vaginal microecology has the characteristics of special,complex,dynamic evolution.The healthy vaginal microbiota(VM),various immune cells and protective proteins together constitute the innate defense system of the female mucosal reproductive tract.With the popularization of microbial multiomics technology in recent years,the importance of vaginal microecology in the occurrence and development of various gynecological infectious diseases such as human papilloma virus(HPV)has been continuously revealed,but the relationship between the two is still unclear.This article will review the research on the correlation between vaginal microecology and common gynecological infectious diseases and focus on the development and progress of HPV infection,the changes in vaginal microecology,the relationship between cervical local immunity and HPV clearance outcome,to provide clinicians with new insights.
作者
郑介婷
张子康
操龙斌
张召
邱峰
ZHENG Jieting;ZHANG Zikang;CAO Longbin;ZHANG Zhao;QIU Feng(School of Traditional Chinese Medicine,Southern Medical University,Guangzhou,Guangdong,China,510515;Department of Laboratory Medicine,The seventh Affiliated Hospital of Southern Medical Universi-ty,Foshan,Guangdong,China,528244;Center of Human Microecology Engineering and Technology of Guangdong Province,Guangzhou,Guangdong,China,510535)
出处
《分子诊断与治疗杂志》
2021年第4期509-513,共5页
Journal of Molecular Diagnostics and Therapy
基金
国家自然科学基金青年项目(82003786)
广东省科技厅基础与应用基础研究基金项目(2019A1515110338)
佛山市中医药领域科技攻关专项(2020001005585)。
关键词
阴道微生态
妇科感染
HPV病毒
The vaginal microbiota
Gynecological infections
HPV
作者简介
通信作者:邱峰,E-mail:QFSFL@126.com。
