摘要
目的:探讨血清雌二醇(E2)联合β-人绒毛促性腺激素(β-hGG)水平对体外受精-胚胎移植(IVF-ET)妊娠结局的预测价值。方法:选择2016年7月—2019年7月于本院生殖中心行IVF-ET治疗并确定妊娠结局的206例不孕患者临床资料进行回顾性分析,根据其妊娠结局并分为单活胎妊娠组、双活胎妊娠组和未妊娠组,比较各组胚胎移植后10、13、16、20 d β-hGG、E2值,建立ROC曲线分析β-hGG、E2对妊娠结局的预测价值。结果:206例IVF-ET治疗后不孕患者经B超和随访确定妊娠终止,其中单活胎妊娠组75例、双活胎妊娠组53例、未妊娠组78例(未妊娠27例、异位妊娠12例、妊娠流产39例)。胚胎移植后10、13、16、20 d,单活胎妊娠组、双活胎妊娠组、未妊娠组β-hGG、E2水平均有差异(P<0.05),β-hGG、E2单独或联合检测均能预测单活胎妊娠或双活胎妊娠(P<0.05),但胚胎移植后13 d对联合检测预测特异度(100%)、20d时联合检测灵敏度(100%)达最高(P<0.05)。结论:血清β-hGG联合E2检测预测妊娠结局价值较高,有望为不孕症患者妊娠成功提供指导。
Objective: To investigate the value of serum estradiol(E2) combined with β-human chorionic gonadotropin(β-HCG) detections for predicting pregnancy outcomes of infertile patients after in vitro fertilization embryo transfer(IVF-ET). Methods: The clinical data of 206 infertile patients who underwent IVF-ET treatment and terminated pregnancy from July 2016 to July 2019 were analyzed retrospectively. These patients were divided into group A(patients with abnormal single-living pregnancy), group B(patients with abnormal double-living pregnancy), and group C(patients with other abnormal pregnancy) according to their pregnancy outcomes. The β-HCG and E2 levels of the patients on 10 th, 13 th, 16 th, and 20 th day after IVF-ET were compared among the three groups. ROC curve was drawn to analyze the value of the levels of β-HCG and E2 for predicting pregnancy outcomes of the patients. Results: 206 infertile patients after IVF-ET had experienced pregnancy termination after confirmed abnormal pregnancy by B-ultrasound and followed up, which included 75 cases with abnormal single live fetus in group A, 53 cases with abnormal double live fetus in group B, and 78 cases in group C(27 patients without pregnancy, 12 patients with ectopic pregnancy, and 39 patients with abortion). There were significant different in the levels of β-HCG and E2 of the patients on the 10 th, 13 th, 16 th and 20 th day after IVF-ET among the three groups(P<0.05). The β-HCG level alone, the E2 level alone, the combination of β-HCG and E2 levels all could predicting the abnormal single or double live fetus of these patients(P<0.05). The combination of β-HCG and E2 levels for predicting the abnormal single or double live fetus on the 13 th day after IVF-ET has the highest specificity(100%), and the sensitivity(100%) of combination of β-HCG and E2 levels for predicting the abnormal single or double live fetus on the 20 th day after IVF-ET was the highest(P<0.05). Conclusion: Serum E2 level combined with β-HCG level for predicting pregnancy outcomes of infertile patients after IVF-ET has a high value, which is expected to provide guidance for the successful pregnancy of infertile patients.
作者
钟树怀
伍玉燕
谢立汉
ZHONG Shuhuai;WU Yuyan;XIE Lihan(Dongguan People's Hospital,Guangdong Province,523059)
出处
《中国计划生育学杂志》
2021年第3期533-536,共4页
Chinese Journal of Family Planning
关键词
不孕
胚胎移植
不同时间
雌二醇
β-人绒毛促性腺激素
预测
妊娠结局
Infertile
Embryo transfer
Different time
Estradiol
β-human villous gonadotropin
Prediction
Pregnancy outcomes
