摘要
目的:探讨参麦注射液对老年晚期乳腺癌患者心力衰竭期心功能及血清N末端B型利钠肽原(NT-proBNP)、超敏心肌肌钙蛋白T(hs-cTnT)的影响。方法:选取2018年6月至2019年12月上海市宝山区中西医结合医院收治的心力衰竭期老年乳腺癌患者94例作为研究对象,采用随机数字法分为对照组(n=47)和观察组(n=47)。对照组患者采用常规对症治疗,观察组患者在对照组的基础上给予参麦注射液治疗。观察两组患者的临床治疗效果,治疗前后心功能指标如左心室射血分数(LVEF)、心排出量(CO)和舒张早期最大血流速度/舒张晚期最大血流速度比值(E/A)等,血清肌酸激酶同工酶(CK-MB)、肌酸激酶(CK)、NTpro BNP和hs-cTnT水平的变化。结果:治疗后,观察组患者的总有效率为87.23%(41/47),明显高于对照组的65.96%(31/47),差异有统计学意义(P<0.05)。治疗后,两组患者LVEF、CO及E/A水平均明显升高,且观察组患者明显优于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者CK-MB、CK、NT-proBNP和hs-cTnT水平明显降低,其中观察组患者的改善程度明显优于对照组,差异均有统计学意义(P<0.05)。结论:参麦注射液通过增强心肌收缩力及抗脂质过氧化作用显著改善老年晚期乳腺癌患者的心功能,降低心肌损伤及心力衰竭风险,提高治疗效果。
OBJECTIVE:To explore the effects of Shenmai injection on heart function,serum N-terminal B-type natriuretic peptide(NT-proBNP)and hypersensitive cardiac troponin T(hs-cTnT)in elderly patients with advanced breast cancer at heart failure stage.METHODS:Totally 94 patients with advanced breast cancer at heart failure stage admitted into Shanghai Baoshan Integrated Hospital of Traditional Chinese and Western Medicine from Jun.2018 to Dec.2019 were extracted to be divided into the control group(n=47)and the observation group(n=47)via the random number table.The control group received conventional symptomatic treatment,while the observation group was treated with Shenmai injection on the basis of the control group.Clinical efficacy,changed of cardiac function such as left ventricular ejection fraction(LVEF),cardiac output(CO),early diastolic maximum flow velocity/late diastolic maximum flow velocity(E/A),serum creatine kinase isoenzyme(CK-MB),creatine kinase(CK),NT-proBNP and hs-cTnT levels before and after treatment were observed in two groups.RESULTS:After treatment,the total effective rate of the observation group was 87.23%(41/47),significantly higher than 65.96%(31/47)of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of LVEF,ratio of CO and E/A in two groups increased significantly,and the observation group was significantly better than the control group,with statistically significant difference(P<0.05).After treatment,the levels of CK-MB,CK,NT-proBNP and hs-cTnT in two groups decreased significantly,and the improvement in the observation group was better than that in the control group,with statistically significant difference(P<0.05).CONCLUSIONS:Shenmai injection can significantly improve the cardiac function of elderly patients with advanced breast cancer by increasing the myocardial contractility and the anti-lipid peroxidation,reducing the risk of myocardial injury and heart failure and improving the clinical efficiency.
作者
唐润薇
李甜
袁帅
李超然
张卫红
TANG Runwei;LI Tian;YUAN Shuai;LI Chaoran;ZHANG Weihong(Dept.of Breast Surgery,Shanghai Baoshan Integrated Hospital of Traditional Chinese and Western Medicine,Shanghai 201900,China)
出处
《中国医院用药评价与分析》
2021年第3期315-318,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
参麦注射液
乳腺癌
心力衰竭
心功能
NT-proBNP
hs-cTnT
Shenmai injection
Breast cancer
Heart failure
Cardiac function
N-terminal B-type natriuretic peptide
Hypersensitive cardiac troponin T
作者简介
唐润薇,主治医师。研究方向:乳腺疾病。E-mail:tking7347@163.com;通信作者:张卫红,主任医师。研究方向:中西医结合三阴性乳腺癌的诊治。E-mail:hongwz1022@sina.com。
