摘要
多发性硬化(MS)是一类自身免疫性疾病,目前全球发病人数不断增长,病理特点主要涉及中枢神经系统炎性浸润伴随的神经胶质细胞增生,髓鞘脱失和轴突损伤等。确切的发病机制尚不十分明确,目前研究结果认为不良生活方式和人体内环境的变化会导致外周免疫细胞的激活,分泌的炎性因子浸润中枢神经系统后引发神经胶质细胞增生,继而发生髓鞘脱失和继发性轴突损伤,临床上多表现为感觉障碍、自主神经功能紊乱、共济失调等。文章对近年来报道的有关外周免疫系统、中枢神经胶质细胞、人体内环境和生活方式在MS发病机制中的作用做一概述。
Multiple sclerosis(MS) is a type of autoimmune disease. Currently, the number of patients with global incidence is increasing. The population of the disease is mainly young and middle-aged, and it is more likely to occur in women. The pathological features mainly involve the inflammatory infiltration of the central nervous system accompanied by the proliferation of glial cells, demyelination and axonal injury. The exact pathogenesis is not very clear. The current research results suggest that poor lifestyle and changes in the human body environment will lead to the activation of peripheral immune cells. The secreted inflammatory factors infiltrate the central nervous system and trigger the proliferation of glial cells, subsequent demyelination and secondery axon injury, which are mostly clinically manifested as sensory disturbances, autonomic nervous dysfunction and ataxia. This article provides an overview of the role of the peripheral immune system, central glial cells, human body environment and lifestyle in the pathogenesis of MS reported in recent years.
作者
孙梦瀛
柴智
樊慧杰
李艳荣
肖午帅
刘建春
尉杰忠
李艳花
张兰芳
张波
肖保国
马存根
SUN Meng-ying;CHAI Zhi;FAN Hui-jie;LI Yan-rong;XIAO Wu-shuai;LIU Jian-chun;YU Jie-zhong;LI Yan-hua;ZHANG Lan-fang;ZHANG Bo;XIAO Bao-guo;MA Cun-gen(Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis/Neurobiology Research Center,Shanxi University of Chinese Medicine,Jinzhong 030619,China;Institute of Brain Science,Shanxi Datong University,Datong 037009,China;Department of Traditional Chinese Medicine,Shanxi Health Vocational College,Jinzhong 030619,China;Huashan Hospital,Fudan University,Institute of Neurology,Shanghai 200025,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2021年第3期1533-1538,共6页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金面上项目(No.81102552,No.81403577,No.81703978)
山西省重点研发计划项目(No.201803D31091,No.201803D31209)
山西省青年拔尖人才支持计划项目(No.晋组办字[2019]35号文)
山西省自然科学基金项目(No.201901D111334)
山西省国际科技合作项目(No.201703D421016)
山西省高等学校科技创新计划项目(No.2019L0724)
基于炎症反应的重大疾病创新药物山西省重点实验室开放课题资助项目(No.SXIDL-2018-04)
山西中医药大学中西医结合防治神经系统疾病研究科技创新团队(No.2018TD-012)
山西省回国留学人员科研资助重点项目(No.2014-7,No.2017-129)
山西省留学人员科技活动项目择优资助项目(No.[2017]19号文)。
作者简介
通信作者:柴智,山西省晋中市高校园区大学街121号山西中医药大学多发性硬化益气活血重点研究室/神经生物学研究中心,邮编:030619,电话:0351-3179952,E-mail:chaizhi008@126.com;马存根,山西省晋中市高校园区大学街121号山西中医药大学多发性硬化益气活血重点研究室/神经生物学研究中心,邮编:030619,电话:0351-3179702,E-mail:macungen2001@163.com。
