摘要
非洲猪瘟(African swine fever,ASF)是由非洲猪瘟病毒(African swine fever virus,ASFV)引起的一种猪烈性传染病。目前无商品化的ASF疫苗,一旦发病,仅能依靠快速扑杀进行防控,严重威胁我国养猪及相关行业的健康发展。ASF疫苗研发面临的主要困难是对ASFV的毒力相关基因、致病及其免疫逃逸机制知之甚少。本文对ASFV的免疫逃逸研究进行了总结,探讨了ASFV免疫逃逸基因及其编码蛋白的功能,以便加深对ASFV及其免疫逃逸策略的认知,为致病机制研究和疫苗研发提供借鉴。
African swine fever(ASF) is a highly contagious, fatal infectious disease of pigs caused by African swine fever virus(ASFV). There is no commercialized vaccine or economical control strategy other than slaughter, which poses a serious threat to the healthy development of the swine industry in China. A major difficulty in the development of ASF vaccines is insufficient knowledge about the virulence-associated genes, the pathogenesis and immunoevasion mechanisms of ASFV. This review summarizes the recent progress in ASFV immunoevasion, discusses the immunoevasion-related functions of ASFV genes and the encoded proteins, which will help understand immunoevasion strategies and mechanisms of ASFV, and provide insights into pathogenesis and vaccine development.
作者
孙茂文
王涛
孙元
杨玉莹
仇华吉
Maowen Sun;Tao Wang;Yuan Sun;Yuying Yang;Hua-Ji Qiu(College of Animal Sciences,Yangtze University,Jingzhou 434023,Hubei Province,China;State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin 150069,Heilongjiang Province,China)
出处
《微生物学报》
CAS
CSCD
北大核心
2021年第2期249-262,共14页
Acta Microbiologica Sinica
基金
国家重点研发计划项目(2017YFD0500601)。
关键词
非洲猪瘟病毒
免疫逃逸
天然免疫
适应性免疫
African swine fever virus
immunoevasion
innate immunity
adaptive immunity
作者简介
通信作者:杨玉莹,Tel/Fax:+86-451-51051708,yangyycn@msn.com;通信作者:仇华吉,E-mail:qiuhuaji@caas.cn。
