摘要
过氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptorγ,PPARγ)是一种配体依赖的核转录因子,属于II型核激素受体超家族成员。以前的研究主要集中于PPARγ在调控脂质代谢、糖代谢、免疫炎症、细胞增殖和分化等方面的作用。随着研究的深入,PPARγ在肿瘤中发挥的作用越来越明显。以往的报道大多集中在PPARγ的抑制肿瘤作用,但最近关于其促进肿瘤的报道也日益增多。该文总结了PPARγ在肿瘤中的最新报道,讨论了其抑制肿瘤和促进肿瘤的双重作用。
PPARγ(peroxisome proliferator-activated receptorγ)is a ligand-dependent nuclear transcription factor and belongs to type II nuclear hormone receptor superfamily.Previous studies focused on the role of PPARγin regulating lipid metabolism,glucose metabolism,immune inflammation,cell proliferation and differentiation.With the deepening of research,the role of PPARγin tumors is becoming more and more clear.Previous reports mostly focused on the tumor-inhibiting effect of PPARγ,but recent reports on its promotion of tumors were also increasing.This article summarized the latest reports of PPARγin tumors and discussed its dual roles in inhibiting and promoting tumor development.
作者
郭鑫
宗欢欢
李杜达
余雨杨
侯凯龙
贾舒婷
GUO Xin;ZONG Huanhuan;LI Duda;YU Yuyang;HOU Kailong;JIA Shuting(Laboratory of Molecular Genetics of Aging and Tumor,Medical school,Kunming University of Science and Technology,Kunming 650500,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2021年第2期460-468,共9页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81760262)
云南省应用基础研究计划项目面上项目(批准号:2019FB109)
云南省“万人计划”青年拔尖人才专项(批准号:YNWR-QNBJ-2019-240)资助的课题。
作者简介
通迅作者:贾舒婷,Tel:13577116928,E-mail:shutingjia@kmust.edu.cn。
