摘要
目的分析和研究加巴喷丁联合奥施康定治疗癌性神经病理性疼痛的疗效。方法选择2016年10月—2019年11月于该院接受治疗的92例恶性肿瘤合并有神经病理性疼痛患者,使用随机分组法将这92例患者随机均分为对照组(46例)和观察组(46例),对照组采用奥施康定单药镇痛治疗方法,观察组采用奥施康定联合加巴喷丁镇痛治疗方法,治疗周期为2周,2周后将两组患者的治疗效果、生活质量及不良反应进行对比。结果观察组完全缓解28例、部分缓解15例、轻度缓解2例、无效缓解1例,对照组完全缓解18例、部分缓解16例、轻度缓解10例、无效缓解2例,两组治疗有效率分别为93.48%和73.91%,观察组明显高于对照组,组间对比差异有统计学意义(χ^(2)=6.452,P<0.05)。观察组Karnofsky分数+稳定者97.83%(45/46)显然高于对照组的80.43%(37/46),差异有统计学意义(χ^(2)=7.180,P<0.05)。两组患者不良反应差异无统计学意义(P>0.05)。结论加巴喷丁联合奥施康定治疗癌性神经病理性疼痛效果确切,可以有效提高患者临床疗效,提高患者患者生活质量。
Objective To analyze and study the efficacy of gabapentin combined with OxyContin in the treatment of cancerous neuropathic pain.Methods The subjects of the study were 92 patients with malignant tumors and neuropathic pain who were treated in the hospital from October 2016 to November 2019.These 92 patients were randomly divided into a control group(46 cases)and an observation group(46 cases)using the randomization method,the control group was treated with OxyContin monotherapy,and the observation group was treated with OxyContin combined with gabapentin.The treatment cycle was 2 weeks.After 2 weeks,the treatment effect,quality of life and adverse effects reactions of the two groups were compared.Results The observation group had 28 cases of complete remission,15 cases of partial remission,2 cases of mild remission,and 1 case of ineffective remission.In the control group,18 cases of complete remission,16 cases of partial remission,10 cases of mild remission,and 2 cases of ineffective remission.The effective rates of treatment were 93.48%and 73.91%respectively.The observation group was significantly higher than that of the control group.The difference was statistically significant(χ^(2)=6.452,P<0.05).The Karnofsky score of the observation group+stable 97.83%(45/46)was obviously higher than that of the control group 80.43%(37/46),which was statistically significant(χ^(2)=7.180,P<0.05).The difference in adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion Gabapentin combined with OxyContin has a definite effect in the treatment of cancerous neuropathic pain.It can effectively improve the clinical efficacy of patients and improve the quality of life of patients.
作者
周宗寿
杨昌来
ZHOU Zong-shou;YANG Chang-lai(Department of Pain,the Third People's Hospital of Yuxi City,Yuxi,Yunnan Province,653100 China)
出处
《世界复合医学》
2021年第1期184-186,共3页
World Journal of Complex Medicine
作者简介
周宗寿(1965-),男,专科,副主任医师,研究方向为疼痛的病因研究及治疗。
